Novel Swine Influenza Virus Subtype H3N1, United States

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Lekcharoensuk, Porntippa ; Lager, Kelly M. ; Vemulapalli, Ramesh ; Woodruff, Mary ; Vincent, Amy L. ; Richt, Jürgen A.
• Description:
  Influenza A virus infects various animal species and transmits among different hosts, especially between humans and swine. Swine may serve as a mixing vessel to create new reassortants that could infect humans. Thus, monitoring and characterizing influenza viruses in swine are important in preventing interspecies transmission. We report the emergence and characterization of a novel H3N1 subtype of swine influenza virus (SIV) in the United States. Phylogenetic analysis showed that the H3N1 SIVs may have acquired the hemagglutinin gene from an H3N2 turkey isolate, the neuraminidase gene from a human H1N1 isolate, and the remaining genes from currently circulating SIVs. The H3N1 SIVs were antigenically related to the turkey virus. Lung lesions and nasal shedding occurred in swine infected with the H3N1 SIVs, suggesting the potential to transmit among swine and to humans. Further surveillance will help determine whether this novel subtype will continue to circulate in swine populations.
• Subjects:
  Amino Acid Sequence Animals Disease Reservoirs Disease Transmission, Infectious Dna, Viral Humans Molecular Sequence Data Orthomyxoviridae Infections Phylogeny Sequence Alignment Species Specificity Swine Swine Diseases Zoonoses

  More +
• Source:
  Emerg Infect Dis. 12(5):787-794.
• Document Type:
  Journal Article
• Place as Subject:
  Indiana ; Michigan
• Volume:
  12
• Issue:
  5
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:2d782837a7bf973b6b13b6af803d35de28cf993656e5d05b9572affa6ce6b19d
• Download URL:
  https://stacks.cdc.gov/view/cdc/16067/cdc_16067_DS1.pdf
• File Type:
  [PDF - 294.20 KB ]