Energy compensation and adiposity in humans

Details

• Alternative Title:
  Curr Biol
• Personal Author:
  Careau, Vincent ; Halsey, Lewis G. ; Pontzer, Herman ; Ainslie, Philip N. ; Andersen, Lene F. ; Anderson, Liam J. ; Arab, Lenore ; Baddou, Issad ; Bedu-Addo, Kweku ; Blaak, Ellen E. ; Blanc, Stephane ; Bonomi, Alberto G. ; Bouten, Carlijn V.C. ; Buchowski, Maciej S. ; Butte, Nancy F. ; Camps, Stefan G.J.A. ; Close, Graeme L. ; Cooper, Jamie A. ; Das, Sai Krupa ; Cooper, Richard ; Dugas, Lara R. ; Eaton, Simon D ; Ekelund, Ulf ; Entringer, Sonja ; Forrester, Terrence ; Fudge, Barry W. ; Goris, Annelies H ; Gurven, Michael ; Hambly, Catherine ; El Hamdouchi, Asmaa ; Hoos, Marije B. ; Hu, Sumei ; Joonas, Noorjehan ; Joosen, Annemiek M. ; Katzmarzyk, Peter ; Kempen, Kitty P. ; Kimura, Misaka ; Kraus, William E. ; Kushner, Robert F. ; Lambert, Estelle V. ; Leonard, William R. ; Lessan, Nader ; Martin, Corby K. ; Medin, Anine C. ; Meijer, Erwin P. ; Morehen, James C. ; Morton, James P. ; Neuhouser, Marian L. ; Nicklas, Theresa A. ; Ojiambo, Robert M. ; Pietiläinen, Kirsi H. ; Pitsiladis, Yannis P. ; Plange-Rhule, Jacob ; Plasqui, Guy ; Prentice, Ross L. ; Rabinovich, Roberto A. ; Racette, Susan B. ; Raichlen, David A. ; Ravussin, Eric ; Reilly, John J. ; Reynolds, Rebecca M. ; Roberts, Susan B. ; Schuit, Albertine J. ; Sjödin, Anders M. ; Stice, Eric ; Urlacher, Samuel S. ; Valenti, Giulio ; Van Etten, Ludo M. ; Van Mil, Edgar A. ; Wells, Jonathan C. K. ; Wilson, George ; Wood, Brian M. ; Yanovski, Jack ; Yoshida, Tsukasa ; Zhang, Xueying ; Murphy-Alford, Alexia J. ; Loechl, Cornelia U. ; Luke, Amy H ; Rood, Jennifer ; Sagayama, Hiro ; Schoeller, Dale A. ; Wong, William W. ; Yamada, Yosuke ; Speakman, John R.
• Corporate Authors:
  IAEA DLW database group
• Description:
  Understanding the impacts of activity on energy balance is crucial. Increasing levels of activity may bring diminishing returns in energy expenditure because of compensatory responses in non-activity energy expenditures.| This suggestion has profound implications for both the evolution of metabolism and human health. It implies that a long-term increase in activity does not directly translate into an increase in total energy expenditure (TEE) because other components of TEE may decrease in response-energy compensation. We used the largest dataset compiled on adult TEE and basal energy expenditure (BEE) (n = 1,754) of people living normal lives to find that energy compensation by a typical human averages 28% due to reduced BEE; this suggests that only 72% of the extra calories we burn from additional activity translates into extra calories burned that day. Moreover, the degree of energy compensation varied considerably between people of different body compositions. This association between compensation and adiposity could be due to among-individual differences in compensation: people who compensate more may be more likely to accumulate body fat. Alternatively, the process might occur within individuals: as we get fatter, our body might compensate more strongly for the calories burned during activity, making losing fat progressively more difficult. Determining the causality of the relationship between energy compensation and adiposity will be key to improving public health strategies regarding obesity.
• Subjects:
  Adiposity Energy Intake Energy Metabolism Humans Obesity
• Keywords:
  Activity Basal Metabolic Rate Daily Energy Expenditure Energy Management Models Exercise Homo Sapiens Trade-offs Weight Loss
• Source:
  Curr Biol. 31(20):4659-4666.e2
• Pubmed ID:
  34453886
• Pubmed Central ID:
  PMC8551017
• Document Type:
  Journal Article
• Funding:
  R01 HL082988/HL/NHLBI NIH HHSUnited States/ ; U01 HL138638/HL/NHLBI NIH HHSUnited States/ ; R01 DK080763/DK/NIDDK NIH HHSUnited States/ ; U01 AG020480/AG/NIA NIH HHSUnited States/ ; U01 AG022132/AG/NIA NIH HHSUnited States/ ; S10 RR026764/RR/NCRR NIH HHSUnited States/ ; P30 DK072476/DK/NIDDK NIH HHSUnited States/ ; P30 DK056341/DK/NIDDK NIH HHSUnited States/ ; N01WH74315/WH/WHI NIH HHSUnited States/ ; R01 AG024119/AG/NIA NIH HHSUnited States/ ; R01 DK080760/DK/NIDDK NIH HHSUnited States/ ; R01 DK069465/DK/NIDDK NIH HHSUnited States/ ; R56 AG067200/AG/NIA NIH HHSUnited States/ ; R01 DP000092/DP/NCCDPHP CDC HHSUnited States/ ; R01 DK074387/DK/NIDDK NIH HHSUnited States/ ; R33 AG070455/AG/NIA NIH HHSUnited States/ ; L30 AA015010/AA/NIAAA NIH HHSUnited States/ ; U01 AR071160/AR/NIAMS NIH HHSUnited States/ ; T32 HL007633/HL/NHLBI NIH HHSUnited States/ ; R01 DK085163/DK/NIDDK NIH HHSUnited States/ ; K23 DK068052/DK/NIDDK NIH HHSUnited States/ ; U01 AG020478/AG/NIA NIH HHSUnited States/ ; R01 CA107545/CA/NCI NIH HHSUnited States/ ; Z99 HD999999/ImNIH/Intramural NIH HHSUnited States/ ; R21 DK098765/DK/NIDDK NIH HHSUnited States/ ; R01 AG029914/AG/NIA NIH HHSUnited States/ ; R01 HD065825/HD/NICHD NIH HHSUnited States/ ; R01 CA119171/CA/NCI NIH HHSUnited States/ ; UL1 TR001414/TR/NCATS NIH HHSUnited States/ ; UG3 DK128298/DK/NIDDK NIH HHSUnited States/ ; RC1 DK086881/DK/NIDDK NIH HHSUnited States/ ; R01 DK030031/DK/NIDDK NIH HHSUnited States/ ; ZIA HD000641/ImNIH/Intramural NIH HHSUnited States/ ; R01 DK056781/DK/NIDDK NIH HHSUnited States/
• Volume:
  31
• Issue:
  20
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:9d6787e30e01cf2128c2b37e1daeab285ec879206b4f6968c7022191c1cd59c7d788651a6bc09e8cbfbc1b2de2fb884ee53790e57072f05f282b363837e675b2
• Download URL:
  https://stacks.cdc.gov/view/cdc/160186/cdc_160186_DS1.pdf
• File Type:
  [PDF - 377.78 KB ]