Prevalence of Carbapenemase-producing Organisms Among Hospitalized Solid Organ Transplant Recipients, Five U.S. Hospitals, 2019–2020

Details

• Alternative Title:
  Transpl Infect Dis
• Personal Author:
  Chan, June L. ; Nazarian, Elizabeth ; Musser, Kimberlee A. ; Snavely, Emily A. ; Fung, Monica ; Doernberg, Sarah B. ; Pouch, Stephanie M. ; Leekha, Surbhi ; Anesi, Judith A. ; Kodiyanplakkal, Rosy Priya ; Turbett, Sarah E. ; Walters, Maroya Spalding ; Epstein, Lauren
• Description:
  Background:
  
  Passive reporting to the Centers for Disease Control and Prevention has identified carbapenemase-producing organisms (CPOs) among solid organ transplant (SOT) recipients, potentially representing an emerging source of spread. We analyzed CPO prevalence in wards where SOT recipients receive inpatient care to inform public health action to prevent transmission.
  
  Methods:
  
  From September 2019 to June 2020, five U.S. hospitals conducted consecutive point prevalence surveys (PPS) of all consenting patients admitted to transplant units, regardless of transplant status. We used the Cepheid Xpert® Carba-R assay to identify carbapenemase genes (blaKPC, blaNDM, blaVIM, blaIMP, blaOXA-48) from rectal swabs. Laboratory-developed molecular tests were used to retrospectively test for a wider range of blaIMP and blaOXA variants.
  
  Results:
  
  In total, 154 patients were screened and 92 (60%) were SOT recipients. CPOs were detected among 7 (8%) SOT recipients, from two of five screened hospitals: 4 blaKPC, 1 blaNDM, 2 blaOXA-23. CPOs were detected in 2 (3%) of 62 non-transplant patients. In three of five participating hospitals, CPOs were not identified among any patients admitted to transplant units.
  
  Conclusions:
  
  Longitudinal surveillance in transplant units, as well as PPS in areas with diverse CPO epidemiology, may inform the utility of routine screening in SOT units to prevent the spread of CPOs.
  
  
• Subjects:
  Bacterial Proteins Beta-Lactamases Hospitals Humans Organ Transplantation Prevalence Retrospective Studies Transplant Recipients
• Keywords:
  Carbapenemase-producing Organism (CPO) Point Prevalence Survey (PPS) Solid Organ Transplant (SOT)
• Source:
  Transpl Infect Dis. 24(2):e13785
• Pubmed ID:
  34989092
• Pubmed Central ID:
  PMC11318107
• Document Type:
  Journal Article
• Funding:
  U60 OE000103/OE/OSELS CDC HHSUnited States/ ; U60OE000103/CC/CDC HHSUnited States/ ; U50 CK000423/CK/NCEZID CDC HHSUnited States/ ; NU50CK000423/CC/CDC HHSUnited States/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  24
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:075f21a3becff27d3c35348c762693558925f73e7e7e16acbc8b3b6d23cda32f9c4683e0b4ffd7621f304f160d069ea2bc631593c0e99f83a9cf21e0a15bab47
• Download URL:
  https://stacks.cdc.gov/view/cdc/159825/cdc_159825_DS1.pdf
• File Type:
  [PDF - 346.90 KB ]