Long-term sustained effects of the Look AHEAD lifestyle intervention on body composition among adults with type 2 diabetes

Details

• Alternative Title:
  Obesity (Silver Spring)
• Personal Author:
  Ashby-Thompson, Maxine ; Heshka, Stanley ; Anderson, Andrea ; Pownall, Henry ; Laferrère, Blandine ; Balasubramanyam, Ashok ; Heymsfield, Steven B. ; Wadden, Thomas ; Gallagher, Dympna
• Corporate Authors:
  Look AHEAD Research Group
• Description:
  Objective:
  
  To test whether there are sustained effects of the Look AHEAD intensive lifestyle intervention (ILI), vs diabetes support and education (DSE), on weight and body composition 12–16 years after randomization.
  
  Research Design and Methods:
  
  Participants were a subset of enrollees in the Look AHEAD DXA substudy that completed the final visit, comprised of men (DSE=99; ILI=94) and women (DSE=134; ILI=135) with type 2 diabetes, mean (±SD) age 57.2±6.4 years and BMI 34.9±5.1 kg/m2 at randomization. Dual energy x-ray absorptiometry measured total and regional fat and lean masses at randomization, Years 1, 4, 8 and final visit. Linear mixed-effects regressions were applied with adjustment for group, clinic, sex, age, race/ethnicity, and baseline body composition.
  
  Results:
  
  Weight and most body compartments were reduced by 2–8% (and BMI 4%) in ILI versus DSE, in men but not women. ILI-induced loss of lean tissue did not show a lower percent lean mass versus DSE at 16 years post randomization.
  
  Conclusion:
  
  ILI-related changes in weight, fat, and lean mass were detectable 12–16 years after randomization in men but, for unknown reasons, not in women. There was no evidence that the intervention led to a disproportionate loss of lean mass by end of study.
  
  
• Subjects:
  Absorptiometry, Photon Aged Body Composition Body Mass Index Diabetes Mellitus, Type 2 Female Humans Life Style Male Middle Aged
• Keywords:
  Body Composition Obesity Weight Loss Maintenance
• Source:
  Obesity (Silver Spring). 32(6):1093-1101
• Pubmed ID:
  38741246
• Pubmed Central ID:
  PMC11301635
• Document Type:
  Journal Article
• Funding:
  DK57177/DK/NIDDK NIH HHSUnited States/ ; U01 DK057154/DK/NIDDK NIH HHSUnited States/ ; DK57219/DK/NIDDK NIH HHSUnited States/ ; U01 DK057182/DK/NIDDK NIH HHSUnited States/ ; U01 DK057177/DK/NIDDK NIH HHSUnited States/ ; U01 DK057078/DK/NIDDK NIH HHSUnited States/ ; M01RR01346/Frederic C. Bartter General Clinical Research Center/ ; DK57149/DK/NIDDK NIH HHSUnited States/ ; Office of Research on Women's Health/ ; U01 DK057149/DK/NIDDK NIH HHSUnited States/ ; LifeScan, Inc., a Johnson & Johnson Company/ ; U01 DK057151/DK/NIDDK NIH HHSUnited States/ ; DK57182/DK/NIDDK NIH HHSUnited States/ ; HL/NHLBI NIH HHSUnited States/ ; RR025758-04/Harvard Clinical and Translational Science Center/ ; DK57171/DK/NIDDK NIH HHSUnited States/ ; P30 DK048520/DK/NIDDK NIH HHSUnited States/ ; U01 DK057135/DK/NIDDK NIH HHSUnited States/ ; R01 AG058571/AG/NIA NIH HHSUnited States/ ; UL1 RR024153/RR/NCRR NIH HHSUnited States/ ; DK57136/DK/NIDDK NIH HHSUnited States/ ; AG058571/AG/NIA NIH HHSUnited States/ ; P30 DK046204/DK/NIDDK NIH HHSUnited States/ ; NR/NINR NIH HHSUnited States/ ; M01 RR002719/RR/NCRR NIH HHSUnited States/ ; Indian Health Service/ ; M01 RR000056/RR/NCRR NIH HHSUnited States/ ; M01RR01066/Massachusetts General Hospital Mallinckrodt General Clinical Research Center and Massachusetts Institute of Technology General Clinical Research Center/ ; U01 DK057219/DK/NIDDK NIH HHSUnited States/ ; National Center on Minority Health and Health Disparities/ ; DK57151/DK/NIDDK NIH HHSUnited States/ ; U01 DK056992/DK/NIDDK NIH HHSUnited States/ ; U01 DK057171/DK/NIDDK NIH HHSUnited States/ ; DK57008/DK/NIDDK NIH HHSUnited States/ ; DK57135/DK/NIDDK NIH HHSUnited States/ ; DK57178/DK/NIDDK NIH HHSUnited States/ ; VA Puget Sound Health Care System Medical Research Service, Department of Veterans Affairs/ ; DK56990/DK/NIDDK NIH HHSUnited States/ ; UL1 RR024153, DK 046204/University of Pittsburgh Clinical and Translational Research Center funded by the Clinical & Translational Science Award/ ; U01 DK057136/DK/NIDDK NIH HHSUnited States/ ; U01 DK057002/DK/NIDDK NIH HHSUnited States/ ; Abbott Nutrition/ ; Hoffmann-La Roche Inc./ ; M01RR0021140/University of Tennessee at Memphis General Clinical Research Center/ ; Health Management Resources/ ; DK57078/DK/NIDDK NIH HHSUnited States/ ; M01 RR001066/RR/NCRR NIH HHSUnited States/ ; U01 DK057131/DK/NIDDK NIH HHSUnited States/ ; M01 RR000051/RR/NCRR NIH HHSUnited States/ ; M01RR00051/University of Colorado Health Sciences Center General Clinical Research Center/ ; Hunter Eastman Scholarship of Translational Research/ ; M01RR000056/University of Pittsburgh General Clinical Research Center/ ; P30 DK026687/DK/NIDDK NIH HHSUnited States/ ; DK57154/DK/NIDDK NIH HHSUnited States/ ; FedEx Corporation/ ; U01 DK056990/DK/NIDDK NIH HHSUnited States/ ; UL1 RR025758/RR/NCRR NIH HHSUnited States/ ; U01 DK057178/DK/NIDDK NIH HHSUnited States/ ; U01 DK057008/DK/NIDDK NIH HHSUnited States/ ; Slim-Fast Brand (Unilever North America)/ ; DK57002/DK/NIDDK NIH HHSUnited States/ ; DK56992/DK/NIDDK NIH HHSUnited States/ ; P30 DK48520/University of Colorado Health Sciences Clinical Nutrition Research Unit/ ; M01RR02719/Johns Hopkins Medical Institutions Bayview General Clinical Research Center/ ; DK57131/DK/NIDDK NIH HHSUnited States/ ; M01 RR001346/RR/NCRR NIH HHSUnited States/ ; P30-DK26687/DK/NIDDK NIH HHSUnited States/ ; OPTIFASTVR (Nestle HealthCare Nutrition) Inc./ ; DK 046204/GF/NIH HHSUnited States/ ; CC/CDC HHSUnited States/
• Volume:
  32
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:3d65df1c6f731ccbd930b1e8d7de2f638bedaab31a248a96283bac065e0f635be3b77b79ad447ad28ec86dd0de04a7f9a4cad37d0d9df676815425a64aa9ec64
• Download URL:
  https://stacks.cdc.gov/view/cdc/159594/cdc_159594_DS1.pdf
• File Type:
  [PDF - 668.94 KB ]