Maternal and Newborn Hospital Outcomes of Perinatal SARS-CoV-2 Infection: A National Registry

Details

• Alternative Title:
  Pediatrics
• Personal Author:
  Hudak, Mark L. ; Flannery, Dustin D. ; Barnette, Kimberly ; Getzlaff, Trace ; Gautam, Shiva ; Dhudasia, Miren B. ; Mukhopadhyay, Sagori ; Pfeifer, Madeline R. ; Ellington, Sascha R. ; Galang, Romeo R. ; Snead, Margaret C. ; Woodworth, Kate R. ; Zapata, Lauren B. ; Puopolo, Karen M.
• Corporate Authors:
  THE AMERICAN ACADEMY OF PEDIATRICS NPC-19 REGISTRY INVESTIGATORS
• Description:
  OBJECTIVES:
  
  The American Academy of Pediatrics National Registry for the Surveillance and Epidemiology of Perinatal coronavirus disease 2019 (COVID-19) (NPC-19) was developed to provide information on the effects of perinatal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
  
  METHODS:
  
  National Registry for the Surveillance and Epidemiology of Perinatal COVID-19 participating centers entered maternal and newborn data for pregnant persons who tested positive for SARS-CoV-2 infection between 14 days before and 10 days after delivery. Incidence of and morbidities associated with maternal and newborn SARS-CoV-2 infection were assessed.
  
  RESULTS:
  
  From April 6, 2020 to March 19, 2021, 242 centers in the United States centers reported data for 7524 pregnant persons; at the time of delivery, 78.1% of these persons were asymptomatic, 18.2% were symptomatic but not hospitalized specifically for COVID-19, 3.4% were hospitalized for COVID-19 treatment, and 18 (0.2%) died in the hospital of COVID-related complications. Among 7648 newborns, 6486 (84.8%) were tested for SARS-CoV-2, and 144 (2.2%) were positive; the highest rate of newborn infection was observed when mothers first tested positive in the immediate postpartum period (17 of 125, 13.6%). No newborn deaths were attributable to SARS-CoV-2 infection. Overall, 15.6% of newborns were preterm: among tested newborns, 30.1% of polymerase chain reaction-positive and 16.2% of polymerase chain reaction-negative were born preterm (P < .001). Need for mechanical ventilation did not differ by newborn SARS-CoV-2 test result, but those with positive tests were more likely to be admitted to a NICU.
  
  CONCLUSIONS:
  
  Early in the pandemic, SARS-CoV-2 infection was acquired by newborns at variable rates and without apparent short-term effects. During a period that preceded widespread availability of vaccines, we observed higher than expected numbers of preterm births and maternal in-hospital deaths.
  
  
• Subjects:
  Child COVID-19 COVID-19 Drug Treatment Female Humans Infant, Newborn Infectious Disease Transmission, Vertical Pregnancy Pregnancy Complications, Infectious Pregnancy Outcome Premature Birth SARS-CoV-2

  More +
• Source:
  Pediatrics. 151(2)
• Pubmed ID:
  36995183
• Pubmed Central ID:
  PMC11292484
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  151
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:d38832c7dc89f5f9454e3fe7a94b47bfb9913069e14b7d116f18253277610cecccc0f1fbdb19e4729002e7794fdb3181573cfc7eed252ff1907731260c8e800f
• Download URL:
  https://stacks.cdc.gov/view/cdc/159529/cdc_159529_DS1.pdf
• File Type:
  [PDF - 483.65 KB ]