Immunogenicity of quadrivalent human papillomavirus vaccine among Alaska Native children aged 9–14 years at 5 years after vaccination

Details

• Alternative Title:
  Vaccine
• Personal Author:
  Davis, Bionca M. ; Blake, Ian ; Panicker, Gitika ; Meites, Elissa ; Thompson, Gail ; Geis, Jesse ; Bruden, Dana ; Fischer, Marc ; Singleton, Rosalyn ; Unger, Elizabeth R. ; Markowitz, Lauri E. ; Bruce, Michael G.
• Description:
  Background:
  
  Persistent human papillomavirus (HPV) infection can cause anogenital and oropharyngeal cancers. Many HPV infections and HPV-associated cancers are vaccine-preventable. Studies suggest long-term persistence of vaccine-induced antibodies. However, data are limited among Alaska Native people.
  
  Methods:
  
  During 2011–2014, we enrolled Alaska Native children aged 9–14 years who received a 3-dose series of quadrivalent HPV vaccine (4vHPV). We collected sera at 1 month and 1, 2, 3, and 5 years post-vaccination to evaluate trends in type-specific immunoglobulin G antibody concentrations for the 4vHPV types (HPV 6/11/16/18).
  
  Results:
  
  All participants (N = 469) had detectable antibodies against all 4vHPV types at all timepoints post-vaccination. For all 4vHPV types, antibody levels peaked by 1 month post-vaccination and gradually declined in subsequent years. At 5 years post-vaccination, antibody levels were higher among children who received 4vHPV at a younger age.
  
  Conclusions:
  
  Alaska Native children maintained antibodies against all 4vHPV types at 5 years post-vaccination.
  
  
• Subjects:
  Adolescent Alaska Alaska Natives Antibodies, Viral Child Female Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18 Humans Immunogenicity, Vaccine Immunoglobulin G Male Papillomavirus Infections Papillomavirus Vaccines Vaccination

  More +
• Keywords:
  Cohort Studies Human Papillomavirus Human Papillomavirus Recombinant Vaccine Quadrivalent Types 6, 11, 16, 18 United States
• Source:
  Vaccine. 42(14):3277-3281
• Pubmed ID:
  38627144
• Pubmed Central ID:
  PMC11285007
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  42
• Issue:
  14
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:aefcb762caae915de92ae7cc4b411d8db2636c756512dcf7be00ebe16739e8ce948abf45ba3b6f789b435a1a5a0b4636185bf6f79d031ee319f715398773acb8
• Download URL:
  https://stacks.cdc.gov/view/cdc/159467/cdc_159467_DS1.pdf
• File Type:
  [PDF - 199.99 KB ]