2023 Invasive Group A Streptococcus Laboratory Testing Survey Report
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2023 Invasive Group A Streptococcus Laboratory Testing Survey Report

Filetype[PDF-1.82 MB]


English
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  • Alternative Title:
    APHL iGAS Laboratory Testing Survey Report |
  • Corporate Authors:
  • Description:
    Group A Streptococcus (GAS) bacteria are commonly found in the throat and on the skin, often causing mild infections like strep throat and impetigo. However, in some cases, GAS bacteria can invade other parts of the body such as the blood, deep muscle, fat tissue and lungs. Invasive GAS (iGAS) can lead to severe and potentially life-threatening conditions, such as cellulitis, pneumonia, necrotizing fasciitis and Streptococcal Toxic Shock Syndrome (STSS).

    The US Centers for Disease Control and Prevention (CDC) reports that in the United States, there are approximately 14,000 to 25,000 cases of iGAS disease each year, resulting in 1,500 to 2,300 annual deaths. CDC closely monitors

    these infections through Active Bacterial Core (ABC) surveillance, involving ten state health departments and laboratories to identify and report cases. Currently, only STSS is nationally reportable, but healthcare providers and laboratories are encouraged to report all iGAS cases to the appropriate health departments, which then report them to CDC through the National Notifiable Diseases Surveillance System.

    There are a variety of laboratory methods used for identification and characterization of GAS, including bacteriology, antimicrobial susceptibility testing (AST), PCR for species identification, toxin testing or emm typing and next generation sequencing (NGS). The M protein, encoded by the emm gene, is a major GAS virulence factor and determining the emm type of iGAS isolates can aid epidemiological and outbreak investigations.

    This project was 100% funded with federal funds from a federal program of $130,000. This publication was supported by Cooperative Agreement # NU60OE000104 from the US Centers for Disease Control and Prevention (CDC). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of CDC.

    Running title: APHL iGAS Laboratory Testing Survey Report

    ID-2024-iGAS-Survey-Report.pdf

  • Subjects:
  • Document Type:
    Pamphlet (or booklet)
  • Funding:
    Cooperative Agreement # NU60OE000104 from the US Centers for Disease Control and Prevention
  • Place as Subject:
    United States
  • Pages in Document:
    5 numbered pages
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