Determination of Mercury with a Miniature Sensor for Point-of-care Testing

Details

• Alternative Title:
  Electroanalysis
• Personal Author:
  Bassi, Caterina Andreasi ; Wu, Zhizhen ; Forst, Linda ; Papautsky, Ian
• Description:
  In developing countries, subsistence gold mining entails mixing metallic mercury with crushed sediments to extract gold. In this approach, the gold-mercury amalgam is heated to evaporate mercury and obtain gold. Thus, the highly volatile mercury can be absorbed through inhalation, resulting in adverse health effects. Urinalysis can be used to detect mercury, which is excreted in urine and feces, and correlate exposure with toxic effects. The current gold standard analytical methods are based on fluorescence or inductively coupled plasma mass spectrometry methods, but are expensive, time consuming, and are not easily accessible in countries where testing is needed. In this work, we report on a miniature electrochemical sensor that can rapidly detect mercury in urine at levels well below the US Biological Exposure Index (BEI) limit of 50 ppb (μg/L). The sensor is based on a thin-film gold electrode and anodic stripping voltammetry electroanalytical approach. The sensor successfully detected mercury at trace levels in urine, with a limit of detection of ~15 ppb Hg in the linear range of 20-80 ppb. With the low-cost disposable sensors and portable instrumentation, it is well suited for point-of-care applications.
• Keywords:
  Anodic Stripping Voltammetry Electrochemical Sensor Mercury Determination Point-of-care Thin Film Gold Sensor Urine
• Source:
  Electroanalysis. 35(3)
• Pubmed ID:
  38894713
• Pubmed Central ID:
  PMC11185419
• Document Type:
  Journal Article
• Funding:
  R33 ES024717/ES/NIEHS NIH HHSUnited States/ ; T42 OH008672/OH/NIOSH CDC HHSUnited States/ ; T42OH008672/ACL/ACL HHSUnited States/
• Volume:
  35
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:0645f0dd03f18481d26a43195bcc3b16113e64163eb59c55299a992cce72f775
• Download URL:
  https://stacks.cdc.gov/view/cdc/158134/cdc_158134_DS1.pdf
• File Type:
  [PDF - 1.55 MB ]