Modelling of Successive Cancer Risks in Lynch Syndrome Families in the presence of competing risks using Copulas

Details

• Alternative Title:
  Biometrics
• Personal Author:
  Choi, Yun-Hee ; Briollais, Laurent ; Win, Aung K ; Hopper, John ; Buchanan, Dan ; Jenkins, Mark ; Chaieb, Lajmi Lakhal
• Description:
  In this article, we propose an association model to estimate the penetrance (risk) of successive cancers in the presence of competing risks. The association between the successive events is modeled via a copula and a proportional hazards model is specified for each competing event. This work is motivated by the analysis of successive cancers for people with Lynch Syndrome in the presence of competing risks. The proposed inference procedure is adapted to handle missing genetic covariates and selection bias, induced by the data collection protocol of the data at hand. The performance of the proposed estimation procedure is evaluated by simulations and its use is illustrated with data from the Colon Cancer Family Registry (Colon CFR).
• Subjects:
  Analysis Of Variance Bias Colonic Neoplasms Colorectal Neoplasms, Hereditary Nonpolyposis Computer Simulation Data Interpretation, Statistical Genetics Humans Proportional Hazards Models Registries Risk

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• Keywords:
  Ascertainment Correction Missing Covariates Penetrance Function Successive Competing Risks
• Source:
  Biometrics. 73(1):271-282
• Pubmed ID:
  27378229
• Pubmed Central ID:
  PMC5319907
• Document Type:
  Journal Article
• Funding:
  HHSN261201000140C/CA/NCI NIH HHSUnited States/ ; U01 CA074799/CA/NCI NIH HHSUnited States/ ; HHSN261201000035C/CA/NCI NIH HHSUnited States/ ; U24 CA074794/CA/NCI NIH HHSUnited States/ ; N01PC35137/CA/NCI NIH HHSUnited States/ ; HHSN261201300012I/CA/NCI NIH HHSUnited States/ ; N01PC35142/CA/NCI NIH HHSUnited States/ ; UM1 CA167551/CA/NCI NIH HHSUnited States/ ; U58 DP003862/DP/NCCDPHP CDC HHSUnited States/ ; U01 CA074783/CA/NCI NIH HHSUnited States/ ; U24 CA074799/CA/NCI NIH HHSUnited States/ ; U01 CA074800/CA/NCI NIH HHSUnited States/ ; HHSN261201300011C/CA/NCI NIH HHSUnited States/ ; U24 CA074783/CA/NCI NIH HHSUnited States/ ; N01 CN067009/CN/NCI NIH HHSUnited States/ ; U24 CA074806/CA/NCI NIH HHSUnited States/ ; HHSN261201300009I/CA/NCI NIH HHSUnited States/ ; HHSN261201300009C/CA/NCI NIH HHSUnited States/ ; U24 CA097735/CA/NCI NIH HHSUnited States/ ; U01 CA074794/CA/NCI NIH HHSUnited States/ ; HHSN261201300021C/CA/NCI NIH HHSUnited States/ ; HHSN261201000035I/CA/NCI NIH HHSUnited States/ ; HHSN261201000034C/CA/NCI NIH HHSUnited States/ ; U01 CA097735/CA/NCI NIH HHSUnited States/ ; U01 CA074806/CA/NCI NIH HHSUnited States/ ; U24 CA074800/CA/NCI NIH HHSUnited States/ ; HHSN261201000121C/CA/NCI NIH HHSUnited States/
• Volume:
  73
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:17fd6ef8c9ded35c0b1eaf49fe0bab404ea63bb664d3acf43c57c1fef37ba29b
• Download URL:
  https://stacks.cdc.gov/view/cdc/158004/cdc_158004_DS1.pdf
• File Type:
  [PDF - 1.07 MB ]