Urinary mutagenicity and oxidative status of wildland firefighters working at prescribed burns in a Midwestern US forest

Details

• Alternative Title:
  Occup Environ Med
• Personal Author:
  Wu, Chieh-Ming ; Warren, Sarah H ; DeMarini, David M ; Song, Chi (Chuck) ; Adetona, Olorunfemi
• Description:
  Objective
  
  Wildland firefighters (WLFFs) experience repeated exposures to wildland fire smoke (WFS).
  
  Methods
  
  A total of 120 spot urine samples was collected from 19 firefighters right before (pre-shift), immediately after (post-shift), and the morning (next-morning) following work shifts on prescribed burn days (burn days) and regular workdays (non-burn days). The levels of urinary mutagenicity, 8-isoprostane, malondialdehyde and oxidised guanine species (Ox-GS) were measured. Linear mixed-effect models were used to determine the difference of cross-shift changes in the concentrations of urinary biomarkers.
  
  Results
  
  Post-shift levels of creatinine-corrected urinary mutagenicity and 8-isoprostane were non-significantly higher than pre-shift levels (1.16× and 1.64×; p=0.09 and 0.07) on burn days. Creatinine-corrected Ox-GS levels increased significantly in next-morning samples following WFS exposure (1.62×, p=0.03). A significant difference in cross-shift changes between burn and non-burn days was observed in 8-isoprostane (2.64×, p=0.03) and Ox-GS (3.00×, p=0.02). WLFFs who contained the fire (performed holding tasks) had a higher pre-morning to next-morning change in urinary mutagenicity compared with those who were lighting fires during the prescribed burns (1.56×, p=0.03).
  
  Conclusions
  
  Compared with the other regions, WLFFs who worked in Midwestern forests had an elevated urinary mutagenicity and systemic oxidative changes associated with WFS exposure at prescribed burns.
  
  
• Source:
  Occup Environ Med.
• Pubmed ID:
  33139344
• Pubmed Central ID:
  PMC10010928
• Document Type:
  Journal Article
• Funding:
  EPA999999/ImEPA/Intramural EPAUnited States/ ; T42OH008455/ACL/ACL HHSUnited States/
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:fba341f72f50c80ec822cc04f45a4a24eaa5e9fccb33d4dcc658821d6b23e708
• Download URL:
  https://stacks.cdc.gov/view/cdc/157914/cdc_157914_DS1.pdf
• File Type:
  [PDF - 378.88 KB ]