Novel Flavivirus or New Lineage of West Nile Virus, Central Europe

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Bakonyi, Tamás ; Hubálek, Zdenek ; Rudolf, Ivo ; Nowotny, Norbert
• Description:
  A flavivirus (strain 97-103) was isolated from Culex pipens mosquitoes in 1997 following floods in South Moravia, Czech Republic. The strain exhibited close antigenic relationship to West Nile virus (WNV) prototype strain Eg-101 in a cross-neutralization test. In this study, mouse pathogenicity characteristics and the complete nucleotide and putative amino acid sequences of isolate 97-103, named Rabensburg virus (RabV) after a nearby Austrian city, were determined. RabV shares only 75%-77% nucleotide identity and 89%-90% amino acid identity with representative strains of WNV lineages 1 and 2. Another RabV strain (99-222) was isolated in the same location 2 years later; it showed >99% nucleotide identity to strain 97-103. Phylogenetic analyses of RabV, WNV strains, and other members of the Japanese encephalitis virus (JEV) complex clearly demonstrated that RabV is either a new (third) lineage of WNV or a novel flavivirus of the JEV group.
• Subjects:
  • Research
  • Rabensburg virus
  • West Nile virus
  • Flaviviridae
  • complete genome analysis
  • phylogenetic analysis
  • research
  • Amino Acid Sequence
  • Animals
  • Animals, Suckling
  More +
• Source:
  Emerg Infect Dis. 11(2):225-231.
• Document Type:
  Journal Article
• Volume:
  11
• Issue:
  2
• Download URL:
  https://stacks.cdc.gov/view/cdc/15737/cdc_15737_DS1.pdf
• File Type:
  [PDF - 292.43 KB]
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:02c578bb85f10f34b9ab6e2914d5e1952e72f1031ed1d6230325ba26e2642c14