Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Bakonyi, Tamás ; Hubálek, Zdenek ; Rudolf, Ivo ; Nowotny, Norbert ;
Bakonyi, Tamás ; Hubálek, Zdenek ; Rudolf, Ivo ; Nowotny, Norbert ; Less -
Description:
A flavivirus (strain 97-103) was isolated from Culex pipens mosquitoes in 1997 following floods in South Moravia, Czech Republic. The strain exhibited close antigenic relationship to West Nile virus (WNV) prototype strain Eg-101 in a cross-neutralization test. In this study, mouse pathogenicity characteristics and the complete nucleotide and putative amino acid sequences of isolate 97-103, named Rabensburg virus (RabV) after a nearby Austrian city, were determined. RabV shares only 75%-77% nucleotide identity and 89%-90% amino acid identity with representative strains of WNV lineages 1 and 2. Another RabV strain (99-222) was isolated in the same location 2 years later; it showed >99% nucleotide identity to strain 97-103. Phylogenetic analyses of RabV, WNV strains, and other members of the Japanese encephalitis virus (JEV) complex clearly demonstrated that RabV is either a new (third) lineage of WNV or a novel flavivirus of the JEV group.
Subject:
[+]
Amino Acid Sequence
Animals
Animals, Suckling
Base Sequence
Complete Genome Analysis
Czech Republic
Female
Flaviviridae
Flavivirus
Flavivirus Infections
Mice
Mice, Inbred ICR
Molecular Sequence Data
Phylogenetic Analysis
Phylogeny
Rabensburg Virus
Research
Reverse Transcriptase Polymerase Chain Reaction
RNA, Viral
Sequence Alignment
Specific Pathogen-Free Organisms
Virulence
West Nile Virus

Source:
Emerg Infect Dis. 11(2):225-231. ;
Document Type:
Journal Article ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:02c578bb85f10f34b9ab6e2914d5e1952e72f1031ed1d6230325ba26e2642c14
File Type:

Supporting Files

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  	license.txt	txt

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