Assisted Reproductive Technology and Perinatal Mortality: Selected States (2006–2011)

Details

• Alternative Title:
  Am J Perinatol
• Personal Author:
  Chang, Jeani ; Zhang, Yujia ; Boulet, Sheree L. ; Crawford, Sara B. ; Copeland, Glenn E. ; Bernson, Dana ; Kirby, Russell S. ; Kissin, Dmitry M. ; Barfield, Wanda D.
• Corporate Authors:
  National Center for Chronic Disease Prevention and Health Promotion.(U.S.), Division of Reproductive Health.
• Description:
  Objective ; This study aimed to compare trends and characteristics of assisted reproductive technology (ART) and non-ART perinatal deaths and to evaluate the association of perinatal mortality and method of conception (ARTvs. non-ART) among ART and non-ART deliveries in Florida, Massachusetts, and Michigan from 2006 to 2011. ; Study Design ; Retrospective cohort study using linked ART surveillance and vital records data from Florida, Massachusetts, and Michigan. ; Results ; During 2006 to 2011, a total of 570 ART-conceived perinatal deaths and 25,158 non-ART conceived perinatal deaths were identified from the participating states. Overall, ART perinatal mortality rates were lower than non-ART perinatal mortality rates for both singletons (7.0/1,000 births vs. 10.2/1,000 births) and multiples (22.8/1,000 births vs. 41.2/1,000 births). At <28 weeks of gestation, the risk of perinatal death among ART singletons was significantly lower than non-ART singletons (adjusted risk ratio aRR = 0.46, 95% confidence interval CI: 0.26–0.85). Similar results were observed among multiples at <28 weeks of gestation (aRR = 0.64, 95% CI: 0.45–0.89). ; Conclusion ; Our findings suggest that ART use is associated with a decreased risk of perinatal deaths prior to 28 weeks of gestation, which may be explained by earlier detection and management of fetal and maternal conditions among ART-conceived pregnancies. These findings provide valuable information for health care providers, including infertility specialists, obstetricians, and pediatricians when counseling ART users on risk of treatment.
• Subjects:
  • Pregnancy
  • Infant, Newborn
  • Female
  • Humans
  • Pregnancy Outcome
  • Infant, Premature
  • Perinatal Death
  • Perinatal Mortality
  • Premature Birth
  • Retrospective Studies
  More +
• Source:
  Am J Perinatol. 40(9):953-959
• Series:
  Assisted Reproductive Technology (ART)
• Subseries:
  Assisted Reproductive Technology Publication
• DOI:
  http://dx.doi.org/10.1055/s-0041-1732451
• Pubmed ID:
  34282572
• Pubmed Central ID:
  PMC11057010
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Genre:
  Research Paper
• Place as Subject:
  United States
• CIO:
  National Center for Chronic Disease Prevention and Health Promotion
• Division:
  Division of Reproductive Health
• Topic:
  Reproductive Health ; Assisted Reproductive Technology
• Location:
  North America
• Volume:
  40
• Issue:
  9
• Download URL:
  https://stacks.cdc.gov/view/cdc/155097/cdc_155097_DS1.pdf
• File Type:
  [PDF - 183.82 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:467c2b89f57d0403e4086af2c51a11f206d0d37e50357e3019ff29e99d6e057621aca336fbed1be3f2ecba84413a19fa522c5c88617068ac7741992e939a007e