Trends in HPV- and non-HPV-Associated Vulvar Cancer Incidence, United States, 2001–2017

Details

• Alternative Title:
  Prev Med
• Personal Author:
  Mix, Jacqueline M. ; Gopalani, Sameer V. ; Simko, Sarah ; Saraiya, Mona
• Description:
  Vulvar cancer incidence has been rising in recent years, possibly due to increasing exposure to human papillomavirus (HPV). We assessed incidence rates of HPV-associated and non-HPV-associated vulvar cancers diagnosed from 2001 to 2017 in the United States (US). Using population-based cancer registry data covering 99% of the US population, incidence rates were calculated and stratified by age, race/ethnicity, stage, geographic region, and histology. The average annual percent change in incidence per year were calculated using joinpoint regression. From 2001 to 2017, the incidence of HPV-associated vulvar cancers increased by 1.2% per year, most notably among women who were aged 50-59 years (2.6%), 60-69 years (2.4%), and ≥ 70 years (0.9%); of White (1.5%) and Black (1.1%) race; diagnosed at an early (1.3%) and late (1.8%) stage; and living in the Midwest (1.9%), Northeast (1.4%), and South (1.2%). Incidence increased each year for HPV-associated histologic subtypes including keratinizing (4.7%), non-keratinizing (6.0%), and basaloid (3.1%) squamous cell carcinomas (SCCs), while decreases were found in warty (2.7%) and microinvasive (5.5%) SCCs. HPV-associated vulvar cancer incidence increased overall and among women aged over 50 years while remaining stable among women younger than 50 years. The overall incidence for non-HPV-associated cancers was stable. Continued surveillance of HPV-associated cancers will allow us to monitor future trends as HPV vaccination coverage increases in the US.
• Subjects:
  Alphapapillomavirus Carcinoma, Squamous Cell Female Humans Incidence Middle Aged Papillomaviridae Papillomavirus Infections United States Vulvar Neoplasms
• Keywords:
  HPV HPV-associated Cancer Incidence Trends Vulvar Cancer
• Source:
  Prev Med. 164:107302
• Pubmed ID:
  36240909
• Pubmed Central ID:
  PMC10999169
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  164
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:85d12f8501ec25d1fd212fa3a8eb9fe410ace0cda56ada7709f1af9c18820904
• Download URL:
  https://stacks.cdc.gov/view/cdc/154103/cdc_154103_DS1.pdf
• File Type:
  [PDF - 111.77 KB ]