Considerations for long-acting antiretroviral therapy in older persons with HIV

Details

• Alternative Title:
  AIDS
• Personal Author:
  O’Shea, Jesse G. ; Cholli, Preetam ; Heil, Emily L. ; Buchacz, Kate
• Description:
  People with HIV (PWH) can now enjoy longer, healthier lives due to safe and highly effective antiretroviral therapy (ART), and improved care and prevention strategies. New drug formulations such as long-acting injectables (LAI) may overcome some limitations and issues with oral antiretroviral therapy and strengthen medication adherence. However, challenges and questions remain regarding their use in aging populations. Here, we review unique considerations for LAI-ART for the treatment of HIV in older PWH, including benefits, risks, pharmacological considerations, implementation challenges, knowledge gaps, and identify factors that may facilitate uptake of LA-ART in this population.
• Subjects:
  Aged Aged, 80 And Over Anti-HIV Agents HIV Infections Humans Injections Medication Adherence
• Keywords:
  Aging Antiretroviral Therapy Cabotegravir Geriatric HIV Injectable Antiretroviral Therapy
• Source:
  AIDS. 37(15):2271-2286
• Pubmed ID:
  37965737
• Pubmed Central ID:
  PMC10993170
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  37
• Issue:
  15
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:2b59280a91dfac5ec4fc63d5092d2e233801381eee47db395de95bbee519ab62702a9f9e58a913bf6e85428679b2e590959494a0445ffd2ed099a8ee21074671
• Download URL:
  https://stacks.cdc.gov/view/cdc/154078/cdc_154078_DS1.pdf
• File Type:
  [PDF - 538.93 KB ]