Determinants of Type-Specific HPV Concordance Across Anatomic Sites in Young Men Who Have Sex with Men and Transgender Women, 3 U.S. Cities, 2016–2018
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4 01 2024
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Source: Sex Transm Dis. 51(4):260-269
Details:
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Alternative Title:Sex Transm Dis
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Personal Author:
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Description:Background:
Among men who have sex with men (MSM) and transgender women (TGW), the dynamics of HPV infections at different anatomical sites are not well understood. Information on HPV concordance between anatomic sites can inform the extent of auto-inoculation, and susceptibility of different anatomic areas to HPV infection. We described and assessed correlates of HPV concordance across anal, oral, and genital samples.
Methods:
We enrolled 1876 MSM and TGW aged 18-26 years in three US cities. Oral, genital, and anal samples were self-collected for type-specific HPV DNA testing (37 types). Demographics, sexual behaviors, and health history were self-reported. Kappa statistics based on percent positive agreement (kappa+) and generalized estimating equations were used to describe and identify correlates of HPV type-specific concordance between anatomic sample pairs.
Results:
Any HPV was detected in 69.9%, 48.6%, and 7.4% of anal, genital, and oral samples, respectively. Detection of any HPV (concurrence) was most common in anal-genital pairs (40.9%) and uncommon in oral-genital and oral-anal pairs (3.4% and 6.5% respectively). Type-specific concordance was poor across all sample pairs (kappa+ <0.20). Younger age and older age at first sex were positively associated with type-concordant anal-genital infections. Sexual behaviors were unassociated with concordance.
Conclusions:
Poor oral/anogenital concordance suggests the oral mucosa has different susceptibility to HPV infection, differential clearance and/or auto-inoculation between oral and anogenital sites is unlikely. There was some observed concurrence and concordance between anal and genital sites, unassociated with sexual behavior, suggesting auto-inoculation. Longitudinal studies are necessary to further elucidate mechanisms of multi-site infections.
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Subjects:
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Source:
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Pubmed ID:38534083
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Pubmed Central ID:PMC10977647
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Document Type:
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Funding:
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Volume:51
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Issue:4
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Supporting Files:No Additional Files