Risk Factors for Human Papillomavirus-Associated Cancers Among People Living with HIV in Washington, District of Columbia

Details

• Alternative Title:
  AIDS Res Hum Retroviruses
• Personal Author:
  Waters, Ansley V. ; Dorsey, Kerri A. ; Allston, Adam ; Woods, Alfreda ; Furness, Bruce W. ; Doshi, Rupali K.
• Description:
  District of Columbia (DC) has high rates of HIV infection and human papillomavirus (HPV)-associated cancers. People living with HIV (PLWH) are at risk for developing HPV-associated cancers. Previous studies identified factors that may further increase the risk of HPV-associated cancer among PLWH such as age, race/ethnicity, sex, risk factor for HIV transmission, stage of HIV infection, and age at HIV diagnosis. The extent to which PLWH in DC are affected by HPV-associated cancers has not previously been well described, and to our knowledge, the relationship between bacterial sexually transmitted infections (STIs) and subsequent development of HPV-associated cancer among PLWH in DC has not been explored. This was a retrospective case-control analysis of surveillance data on cancer, STIs, and HIV in Washington, DC from 1996 to 2015. There were 20,744 PLWH included in this study, of whom 335 (1.6%) had been diagnosed with an HPV-associated cancer. Among males living with HIV (MLWH), for every additional STI per 10 person-years, risk of developing an HPV-associated cancer increased by 11%. Exposure to STIs was not a significant risk factor for HPV-associated cancer among females. Ever being diagnosed with stage three HIV infection increased risk of HPV-associated cancers among males by 109% and females living with HIV by 111%. STI exposures were associated with HPV-associated cancers among MLWH in DC and ever being diagnosed with advanced HIV infection was associated with HPV-associated cancers among all PLWH. Clinicians treating MLWH should ensure their patients receive primary HPV infection prevention and HPV-associated cancer screenings.
• Subjects:
  District Of Columbia Female HIV Infections Human Papillomavirus Viruses Humans Male Neoplasms Papillomavirus Infections Retrospective Studies Risk Factors
• Keywords:
  HIV HPV-associated Cancer Sexually Transmitted Infection
• Source:
  AIDS Res Hum Retroviruses. 39(4):195-203
• Pubmed ID:
  36656664
• Pubmed Central ID:
  PMC10958483
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  39
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:85ce876bd598757805d55237f7c92f24ac6803482d569f59bc90d8e3e656583e
• Download URL:
  https://stacks.cdc.gov/view/cdc/153483/cdc_153483_DS1.pdf
• File Type:
  [PDF - 225.39 KB ]