Increase in Invasive Serogroup Y Meningococcal Disease in the United States [March 28, 2024, 1:30 PM ET]

Details

• Corporate Authors:
  Centers for Disease Control and Prevention (U.S.). Health Alert Network (HAN)
• Description:
  March 28, 2024, 1:30 PM ET
  
  CDCHAN-00505
  
  The Centers for Disease Control and Prevention (CDC) is issuing this Health Alert Network (HAN) Health Advisory to alert healthcare providers to an increase in invasive meningococcal disease, mainly attributable to Neisseria meningitidis serogroup Y (Figure). In 2023, 422 cases were reported in the United States, the highest annual number of cases reported since 2014. As of March 25, 2024, 143 cases have been reported to CDC for the current calendar year, an increase of 62 cases over the 81 reported as of this date in 2023. A specific meningococcal strain, sequence type (ST) 1466, is responsible for most (101 of 148, 68%) serogroup Y cases with available sequence type data that were reported across the United States in 2023. Cases caused by this strain are disproportionately occurring in people ages 30–60 years (65%), Black or African American people (63%), and people with HIV (15%). In addition, most cases of invasive meningococcal disease caused by ST-1466 in 2023 had a clinical presentation other than meningitis: 64% presented with bacteremia, and at least 4% presented with septic arthritis. Of 94 patients with known outcomes, 17 (18%) died; this case-fatality rate is higher than the historical case-fatality rate of 11% reported for serogroup Y cases in 2017–2021. Healthcare providers should 1) have a heightened suspicion for meningococcal disease, particularly among populations disproportionately affected by the current increase, 2) be aware that patients may present without symptoms typical of meningitis, and 3) ensure that all people recommended for meningococcal vaccination, including people with HIV, are up to date for meningococcal vaccines.
  
  
• Content Notes:
  Notice of Possible Alert Expiration: The CDC Health Alert, Advisory, Update, and Info Service announcements, distributed by the Health Alert Network (HAN), were active on the date they were originally published. Publication dates have been added to Titles for clarity. A CDC Health Alert, Advisory, Update, and Info Service announcement may expire at any time. They may also be updated or superseded according to later developments. None of the CDC Health Alert, Advisory, Update, or Info Service announcements in the Stacks HAN Collection should be assumed to be current or active. Stacks preserves HAN announcements in order to maintain a record of past CDC actions. Stacks in not designed for up-to-the-minute notifications. For the list of current CDC Health Alert, Advisory, Update, or Info Service announcements, patrons should visit the Health Alert Network (HAN) webpage at https://www.cdc.gov/han/php/about/index.html. For up to the minute reports, subscribe to the HAN email alert system hosted by CDC News & Updates at https://tools.cdc.gov/campaignproxyservice/subscriptions.aspx?topic_id=USCDC_486
  
  Categories of Health Alert Network (HAN) messages:
  
  Health Alert: Requires immediate action or attention, highest level of importance.
  
  Health Advisory: May not require immediate action; provides important information for a specific incident or situation.
  
  Health Update: Unlikely to require immediate action; provides updated information regarding an incident or situation.
  
  HAN Info Service: Does not require immediate action; provides general public health information.
  
  
• Subjects:
  Meningococcal Infections/epidemiology Meningococcal Infections/prevention & Control Meningococcal Vaccines Neisseria Meningitidis Neisseria Meningitidis, Serogroup Y
• Keywords:
  HAN Health Alert Network
• Source:
  HAN ; 505
• Series:
  Health Alert Network
• Subseries:
  CDC Health Advisory
• Publisher:
  Centers for Disease Control and Prevention (CDC) (U.S.)
• Document Type:
  Text
• Genre:
  Alert
• Rights:
  Public Domain
• Issue:
  00505
• Collection(s):
  Health Alert Network (HAN)
• Main Document Checksum:
  urn:sha-512:b9c074c6ec512ea3ab0d3cfd122fd15259d63606d835fc16f21fe6574a9dbd54a268da1fb0394acf043b0a2d3506fe284833843a1f845a8dea0cfa229aff1238
• Download URL:
  https://stacks.cdc.gov/view/cdc/151975/cdc_151975_DS1.pdf
• File Type:
  [PDF - 164.64 KB ]