Clinical characteristics of the West Nile fever outbreak, Israel, 2000.

Chowers, M. Y.; Lang, R.; Nassar, F.; Ben-David, D.; Giladi, M.; Rubinshtein, E.; Itzhaki, A.; Mishal, J.; Siegman-Igra, Y.; Kitzes, R.; Pick, N.; Landau, Z.; Wolf, D.; Bin, H.; Mendelson, E.; Pitlik, S. D.; Weinberger, M.

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Clinical characteristics of the West Nile fever outbreak, Israel, 2000.

Published Date:

2001 Jul-Aug

Source:

Emerg Infect Dis. 7(4):675-678.

[PDF-56.09 KB]

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Personal Authors:

Chowers, M. Y. ; Lang, R. ; Nassar, F. ; Ben-David, D. ; Giladi, M. ; ... More ▼

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Description:

West Nile (WN) virus is endemic in Israel. The last reported outbreak had occurred in 1981. From August to October 2000, a large-scale epidemic of WN fever occurred in Israel; 417 cases were confirmed, with 326 hospitalizations. The main clinical presentations were encephalitis (57.9%), febrile disease (24.4%), and meningitis (15.9%). Within the study group, 33 (14.1%) hospitalized patients died. Mortality was higher among patients >70 years (29.3%). On multivariate regressional analysis, independent predictors of death were age >70 years (odds ratio [OR] 7.7), change in level of consciousness (OR 9.0), and anemia (OR 2.7). In contrast to prior reports, WN fever appears to be a severe illness with high rate of central nervous system involvement and a particularly grim outcome in the elderly.

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

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