Health and economic impact of the United States varicella vaccination program, 1996–2020

Details

• Alternative Title:
  J Infect Dis
• Personal Author:
  Zhou, Fangjun ; Leung, Jessica ; Marin, Mona ; Dooling, Kathleen L. ; Anderson, Tara C. ; Ortega-Sanchez, Ismael R.
• Description:
  Objective:
  
  To evaluate the health and economic impact of the varicella vaccination program on varicella disease in the United States (U.S.), 1996–2020.
  
  Design:
  
  Analysis was conducted using the Centers for Disease Control and Prevention or published annual population-based varicella incidence, and varicella-associated hospitalization, outpatient visit, and mortality rates during 1996–2020 compared to before vaccination (1990–1994). Disease costs were estimated using the societal perspective. Vaccination program costs included costs of vaccine, administration, post-vaccination adverse events, and travel and work time lost to obtain vaccination. All costs were adjusted to 2020 US dollars using a 3% annual discount rate.
  
  Setting:
  
  U.S. population aged 0–49 years during 1996–2020 (range: 199.5 million to 214.2 million persons).
  
  Main outcome measures:
  
  Number of varicella-associated cases, hospitalizations, hospitalization days, and premature deaths prevented; life-years saved; and net societal savings from the U.S. varicella vaccination program.
  
  Results:
  
  Among U.S. persons aged 0–49 years, during 1996 through 2020, it is estimated that more than 91 million varicella cases, 238,000 hospitalizations, 1.1 million hospitalization days, and almost 2000 deaths were prevented, and 118,000 life-years were saved by the varicella vaccination program, at net societal savings of $23.4 billion.
  
  Conclusion:
  
  Varicella vaccination has resulted in substantial disease prevention and societal savings for the U.S. over 25 years of program implementation.
  
  
• Subjects:
  Chickenpox Cost Of Illness Humans Immunization Programs United States Vaccination Vaccines
• Keywords:
  Benefit Cost Varicella Disease Varicella Vaccine (VAR)
• Source:
  J Infect Dis. 226(Suppl 4):S463-S469
• Pubmed ID:
  36265847
• Pubmed Central ID:
  PMC10941259
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  226
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:35a69bfddb55cc8d046286c3945d9582d5023618d51aa6bb8391a984cef58ecf
• Download URL:
  https://stacks.cdc.gov/view/cdc/151724/cdc_151724_DS1.pdf
• File Type:
  [PDF - 328.15 KB ]