Features of Knee and Multi-joint Osteoarthritis by Sex and Race/Ethnicity: A Preliminary Analysis in the Johnston County Health Study

Details

• Alternative Title:
  J Rheumatol
• Personal Author:
  Novin, Sherwin ; Alvarez, Carolina ; Renner, Jordan B. ; Golightly, Yvonne M. ; Nelson, Amanda E.
• Description:
  Objective:
  
  To evaluate knee and multi-joint osteoarthritis (KOA and MJOA) and compare features by sex and race/ethnicity in a population-based cohort.
  
  Methods:
  
  Participants (n=544) enrolled in the Johnston County Health Study (JoCoHS) as of January 2023 were categorized by radiographic and symptomatic KOA and MJOA phenotypes and frequencies were compared by sex and race/ethnicity. Symptoms were assessed according to the Knee and Osteoarthritis Outcomes Scores (KOOS) and pain, aching, stiffness scores (PAS) at various joints. Models produced adjusted (for age, BMI, education) estimates (odds ratios [OR] or mean ratios [MR] and 95% confidence intervals [CI]).
  
  Results:
  
  Men had twice the odds of MJOA-6 (at least three lower extremity joints); there were no significant differences in MJOA phenotypes by race. Women had 50% higher odds of KOA along with various features of KOA. Women reported significantly worse KOOS symptoms scores (MR = 1.25). Black participants had higher odds of more severe KOA (OR=1.47), subchondral sclerosis (OR=2.06) and medial tibial osteophytes (OR=1.50). Black participants reported worse KOOS symptoms than White participants (MR= 1.18). Although not statistically significant, Hispanics (versus non-Hispanics) appeared to have lower odds of radiographic changes but reported worse symptoms.
  
  Conclusion:
  
  Preliminary findings in the diverse JoCoHS cohort suggest more lower extremity predominant MJOA in men compared to women. Women and Black participants had more KOA features and more severe symptoms. Hispanic participants appear to have higher pain and symptoms scores despite having fewer structural changes. Studies in diverse populations are needed to understand the burden of OA.
  
  
• Keywords:
  Arthritis Knee Knee Joint Osteoarthritis Pain Sex
• Source:
  J Rheumatol.
• Pubmed ID:
  37714542
• Pubmed Central ID:
  PMC10940227
• Document Type:
  Journal Article
• Funding:
  K24 AR081368/AR/NIAMS NIH HHSUnited States/ ; P30 AR072580/AR/NIAMS NIH HHSUnited States/ ; R01 AR077060/AR/NIAMS NIH HHSUnited States/ ; U01 DP006266/DP/NCCDPHP CDC HHSUnited States/
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:da32bdd8c6e5edd2dc64b858914eda03e5116ab14ec4a628040c658b7de7da79e199ea424d53d35412fa776d09c0212092043d3381c6f8ef770a6d5fbe79449c
• Download URL:
  https://stacks.cdc.gov/view/cdc/151720/cdc_151720_DS1.pdf
• File Type:
  [PDF - 276.92 KB ]