Details:

Alternative Title:
Osteoarthritis Cartilage
Personal Author:
Nelson, Amanda E.
Description:
Objective:

To summarize the current state of the literature regarding multi-joint osteoarthritis (MJOA) and discuss important future directions.

Design:

Narrative review of the author’s work and other key references on this topic with a focus on the Johnston County studies, definitions of MJOA and their impact, multi-site pain in OA, genetics and biomarkers in MJOA, and perspectives on future work.

Results:

MJOA is variably defined and lacks a clear consensus definition, making comprehensive study challenging. Involvement of both symptoms and structural changes of OA in multiple joints in an individual is common, but patterns vary by sex, race/ethnicity, and other factors. Outcomes (e.g., general health, function, falls, mortality) are negatively impacted by greater whole body OA burden. Recent genetic and biomarker studies including whole body OA assessments have begun to shed some light on potentially unique factors in the MJOA population.

Conclusions:

Consideration of MJOA is essential for ongoing study of OA phenotypes, epidemiology, risk factors, genetics, biomarkers, and outcomes, to fully understand and eventually limit the negative impact of OA burden on health.


Subjects:
[+]
Biomarkers Ethnicity Humans North Carolina Osteoarthritis Phenotype
Keywords:
[+]
Biomarkers Epidemiology Generalized Osteoarthritis Multi-joint Osteoarthritis
Source:
Osteoarthritis Cartilage. 32(3):234-240
Pubmed ID:
37984559
Pubmed Central ID:
PMC10922529
Document Type:
Journal Article
Funding:
K24 AR081368/AR/NIAMS NIH HHSUnited States/ ; R01 AR080742/AR/NIAMS NIH HHSUnited States/ ; U01 DP006266/DP/NCCDPHP CDC HHSUnited States/ ; R01 AR080733/AR/NIAMS NIH HHSUnited States/ ; R01 AR078187/AR/NIAMS NIH HHSUnited States/ ; ... More +
K24 AR081368/AR/NIAMS NIH HHSUnited States/ ; R01 AR080742/AR/NIAMS NIH HHSUnited States/ ; U01 DP006266/DP/NCCDPHP CDC HHSUnited States/ ; R01 AR080733/AR/NIAMS NIH HHSUnited States/ ; R01 AR078187/AR/NIAMS NIH HHSUnited States/ ; P60 AR064166/AR/NIAMS NIH HHSUnited States/ ; U01 DP003206/DP/NCCDPHP CDC HHSUnited States/ ; P30 AR072580/AR/NIAMS NIH HHSUnited States/ ; R01 AR077060/AR/NIAMS NIH HHSUnited States/ Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:3978e79da587d9c250d0f5b8eee03ea58849364a6812ef4b1d21c52db9ce541f
File Type:

• Supporting Files:
  No Additional Files

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