CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.
As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.
i
Adaptation of Bordetella pertussis to vaccination: a cause for its reemergence?
-
2001
-
-
Source: Emerg Infect Dis. 7(3 Suppl):526-528.
[PDF-401.19 KB]
Details:
-
Alternative Title:Emerg Infect Dis
-
Personal Author:
-
Description:In the Netherlands, as in many other western countries, pertussis vaccines have been used extensively for more than 40 years. Therefore, it is conceivable that vaccine-induced immunity has affected the evolution of Bordetella pertussis. Consistent with this notion, pertussis has reemerged in the Netherlands, despite high vaccination coverage. Further, a notable change in the population structure of B. pertussis was observed in the Netherlands subsequent to the introduction of vaccination in the 1950s. Finally, we observed antigenic divergence between clinical isolates and vaccine strains, in particular with respect to the surface-associated proteins pertactin and pertussis toxin. Adaptation may have allowed B. pertussis to remain endemic despite widespread vaccination and may have contributed to the reemergence of pertussis in the Netherlands.
-
Subjects:
-
Source:
-
Document Type:
-
Volume:7
-
Collection(s):
-
Main Document Checksum:
-
Download URL:
-
File Type:
