Cryptococcus neoformans infection in organ transplant recipients: variables influencing clinical characteristics and outcome.

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Husain, S. ; Wagener, M. M. ; Singh, N.
• Description:
  Unique clinical characteristics and other variables influencing the outcome of Cryptococcus neoformans infection in organ transplant recipients have not been well defined. From a review of published reports, we found that C. neoformans infection was documented in 2.8% of organ transplant recipients (overall death rate 42%). The type of primary immunosuppressive agent used in transplantation influenced the predominant clinical manifestation of cryptococcosis. Patients receiving tacrolimus were significantly less likely to have central nervous system involvement (78% versus 11%, p =0.001) and more likely to have skin, soft-tissue, and osteoarticular involvement (66% versus 21%, p = 0.006) than patients receiving nontacrolimus- based immunosuppression. Renal failure at admission was the only independently significant predictor of death in these patients (odds ratio 16.4, 95% CI 1.9-143, p = 0.004). Hypotheses based on these data may elucidate the pathogenesis and may ultimately guide the management of C. neoformans infection in organ transplant recipients.
• Subjects:
  Adolescent Adult Aged Child Cryptococcosis Female Humans Male Middle Aged Organ Transplantation Time Factors

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• Source:
  Emerg Infect Dis. 7(3):375-381.
• Document Type:
  Journal Article
• Volume:
  7
• Issue:
  3
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:6a1a65162bea955407675ff064788f535bbc0e8fda4b3591063f5bce7b271a9c
• Download URL:
  https://stacks.cdc.gov/view/cdc/15112/cdc_15112_DS1.pdf
• File Type:
  [PDF - 68.69 KB ]