Risk Prediction Score for Chronic Kidney Disease in Healthy Adults and Adults With Type 2 Diabetes: Systematic Review

Details

• Journal Article:
  Preventing Chronic Disease (PCD)
• Personal Author:
  González-Rocha, Alejandra ; Colli, Victor A. ; Denova-Gutiérrez, Edgar
• Description:
  Introduction
  
  Chronic kidney disease (CKD) is an important public health problem. In 2017, the global prevalence was estimated at 9.1%. Appropriate tools to predict the risk of developing CKD are necessary to prevent its progression. Type 2 diabetes is a leading cause of CKD; screening the population living with the disease is a cost-effective solution to prevent CKD. The aim of our study was to identify the existing prediction scores and their diagnostic accuracy for detecting CKD in apparently healthy populations and populations with type 2 diabetes.
  
  Methods
  
  We conducted an electronic search in databases, including Medline/PubMed, Embase, Health Evidence, and others. For the inclusion criteria we considered studies with a risk predictive score in healthy populations and populations with type 2 diabetes. We extracted information about the models, variables, and diagnostic accuracy, such as area under the receiver operating characteristic curve (AUC), C statistic, or sensitivity and specificity.
  
  Results
  
  We screened 2,359 records and included 13 studies for healthy population, 7 studies for patients with type 2 diabetes, and 1 for both populations. We identified 12 models for patients with type 2 diabetes; the range of C statistic was from 0.56 to 0.81, and the range of AUC was from 0.71 to 0.83. For healthy populations, we identified 36 models with the range of C statistics from 0.65 to 0.91, and the range of AUC from 0.63 to 0.91.
  
  Conclusion
  
  This review identified models with good discriminatory performance and methodologic quality, but they need more validation in populations other than those studied. This review did not identify risk models with variables comparable between them to enable conducting a meta-analysis.
  
  
• Subjects:
  Adult Diabetes Mellitus, Type 2 Humans Renal Insufficiency, Chronic Risk Factors ROC Curve
• Source:
  Prev Chronic Dis. 2023; 20
• DOI:
  http://dx.doi.org/10.5888/pcd20.220380
• ISSN:
  1545-1151
• Pubmed ID:
  37079751
• Pubmed Central ID:
  PMC10159345
• Document Type:
  Journal Article
• Genre:
  Systematic Review
• Volume:
  20
• Collection(s):
  Preventing Chronic Disease
• Main Document Checksum:
  urn:sha-512:c159ba240afdb802ba24e711e2180380a7718c43d8793f97e4343ec84c09a25ed6649196394920e9ff6ddfaf2bcd2b8798769501e752633e75213125d22bdb8d
• Download URL:
  https://stacks.cdc.gov/view/cdc/150999/cdc_150999_DS1.pdf
• File Type:
  [PDF - 749.99 KB ]