Pathogenesis and transmission assessment of three swine-origin influenza A(H3N2) viruses with zoonotic risk to humans isolated in the U.S from 2017–2020

Sun, Xiangjie; Belser, Jessica A.; Pulit-Penaloza, Joanna A.; Brock, Nicole; Pappas, Claudia; Zanders, Natosha; Jang, Yunho; Jones, Joyce; Tumpey, Terrence M.; Davis, C. Todd; Maines, Taronna R.

doi:10.1093/infdis/jiad359

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Pathogenesis and transmission assessment of three swine-origin influenza A(H3N2) viruses with zoonotic risk to humans isolated in the U.S from 2017–2020

4 12 2024
By Sun, Xiangjie ; Belser, Jessica A. ; Pulit-Penaloza, Joanna A. ; ...
Source: J Infect Dis. 229(4):1107-1111

Public Access Version Available on: October 12, 2024, 12:00 AM

Please check back on the date listed above.

English

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Alternative Title:

J Infect Dis
Personal Author:

Sun, Xiangjie ; Belser, Jessica A. ; Pulit-Penaloza, Joanna A. ; Brock, Nicole ; Pappas, Claudia ; ... More +

Sun, Xiangjie ; Belser, Jessica A. ; Pulit-Penaloza, Joanna A. ; Brock, Nicole ; Pappas, Claudia ; Zanders, Natosha ; Jang, Yunho ; Jones, Joyce ; Tumpey, Terrence M. ; Davis, C. Todd ; Maines, Taronna R. Less -
Description:

The sporadic occurrence of human infections with swine-origin influenza A(H3N2) viruses and the continual emergence of novel A(H3N2) viruses in swine herds underscore the necessity for ongoing assessment of the pandemic risk posed by these viruses. Here, we selected 3 recent novel swine-origin A(H3N2) viruses isolated between 2017 to 2020, bearing hemagglutinins from the 1990.1, 2010.1, or 2010.2 clades, and evaluated their ability to cause disease and transmit in a ferret model. We conclude that despite considerable genetic variances, all 3 contemporary swine-origin A(H3N2) viruses displayed a capacity for robust replication in the ferret respiratory tract and were also capable of limited airborne transmission. These findings highlight the continued public health risk of swine-origin A(H3N2) strains, especially in human populations with low cross-reactive immunity.
Subjects:

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Animals Ferrets Humans Influenza, Human Influenza A Virus Influenza A Virus, H3N2 Subtype Orthomyxoviridae Infections Swine Swine Diseases United States
Source:

J Infect Dis. 229(4):1107-1111
Pubmed ID:

37602528
Pubmed Central ID:

PMC10879443
Document Type:

Journal Article
Funding:

CC999999/ImCDC/Intramural CDC HHSUnited States/
Collection(s):

CDC Public Access
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urn:sha-512:5752022b36b82e4d4e0554948ffa89741d23342b71eb76c31e7b30eeec38e01f9a7cf31e9875e4896fbc41453db9d559b9b1ce468ced2e35593aa33569356a76
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