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The role of unit-dose child-resistant packaging in unintentional childhood exposures to buprenorphine-naloxone tablets
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Feruary 2020
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[PDF-361.84 KB]
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Description:Buprenorphine-naloxone was among the most commonly implicated exposures in pediatric emergency department (ED) visits for unsupervised oral prescription medication ingestions in 2007-2011, resulting in high hospitalization rates [1, 2] and several deaths.[3] Buprenorphine-naloxone products are available as sublingual tablets and, since 08/2010, as sublingual film dispensed in child-resistant unit-dose packaging (UDP). Buprenorphine-naloxone tablets are dispensed in multidose bottles, and, since 07/2013, also in UDP. Several studies have detected decreasing rates of childhood exposures for buprenorphine-naloxone products since the introduction of the film,[2, 4] and lower rates associated with the film compared to the tablet.[3] However, only one study distinguished between the effects of the dosage form and UDP.[4] Wang et al. detected a statistically significant decline in poison control calls for childhood exposures to buprenorphine-naloxone tablets with increasing UDP use; however, the extent of decline far exceeded the UDP dispensing rate. To further investigate the effects of UDP, we compared ED visit rates for pediatric ingestion of buprenorphine-naloxone tablets prior to the introduction of UDP (2008-2011) with rates after the introduction of UDP (2015-2017), excluding a transition period.
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Pubmed ID:31745829
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Pubmed Central ID:PMC10610465
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Volume:43
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Issue:2
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