The role of unit-dose child-resistant packaging in unintentional childhood exposures to buprenorphine-naloxone tablets

Details

• Personal Author:
  Hampp, Christian ; Lovegrove, Maribeth C. ; Budnitz, Daniel S. ; Mathew, Justin ; Ho, Amy ; McAninch, Jana
• Corporate Authors:
  Centers for Disease Control and Prevention (U.S.). Division of Healthcare Quality Promotion
• Description:
  Buprenorphine-naloxone was among the most commonly implicated exposures in pediatric emergency department (ED) visits for unsupervised oral prescription medication ingestions in 2007-2011, resulting in high hospitalization rates [1, 2] and several deaths.[3] Buprenorphine-naloxone products are available as sublingual tablets and, since 08/2010, as sublingual film dispensed in child-resistant unit-dose packaging (UDP). Buprenorphine-naloxone tablets are dispensed in multidose bottles, and, since 07/2013, also in UDP. Several studies have detected decreasing rates of childhood exposures for buprenorphine-naloxone products since the introduction of the film,[2, 4] and lower rates associated with the film compared to the tablet.[3] However, only one study distinguished between the effects of the dosage form and UDP.[4] Wang et al. detected a statistically significant decline in poison control calls for childhood exposures to buprenorphine-naloxone tablets with increasing UDP use; however, the extent of decline far exceeded the UDP dispensing rate. To further investigate the effects of UDP, we compared ED visit rates for pediatric ingestion of buprenorphine-naloxone tablets prior to the introduction of UDP (2008-2011) with rates after the introduction of UDP (2015-2017), excluding a transition period.
• Subjects:
  Drug Overdose / Epidemiology Drug Packaging / Statistics & Numerical Data Pediatric Emergency Medicine / Statistics & Numerical Data
• Pubmed ID:
  31745829
• Pubmed Central ID:
  PMC10610465
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHS/United States
• Volume:
  43
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:996d9df8807b5ce7ee34a12ea8adfba0fb85726c40426ee5200b182866b634bc
• Download URL:
  https://stacks.cdc.gov/view/cdc/149106/cdc_149106_DS1.pdf
• File Type:
  [PDF - 361.84 KB ]