Concurrent Clade I and Clade II Monkeypox Virus Circulation, Cameroon, 1979–2022

Djuicy, Delia D.; Sadeuh-Mba, Serge A.; Bilounga, Chanceline N.; Yonga, Martial G.; Tchatchueng-Mbougua, Jules B.; Essima, Gael D.; Esso, Linda; Nguidjol, Inès M.E.; Metomb, Steve F.; Chebo, Cornelius; Agwe, Samuel M.; Ankone, Placide A.; Ngonla, Firmin N.N.; Mossi, Hans M.; Etoundi, Alain G.M.; Eyangoh, Sara I.; Kazanji, Mirdad; Njouom, Richard

doi:10.3201/eid3003.230861

i

Concurrent Clade I and Clade II Monkeypox Virus Circulation, Cameroon, 1979–2022

Supporting Files Public Domain

3 2024
By Djuicy, Delia D. ; Sadeuh-Mba, Serge A. ; Bilounga, Chanceline N. ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Djuicy, Delia D. ; Sadeuh-Mba, Serge A. ; Bilounga, Chanceline N. ; Yonga, Martial G. ; Tchatchueng-Mbougua, Jules B. ; Essima, Gael D. ; Esso, Linda ; Nguidjol, Inès M.E. ; Metomb, Steve F. ; Chebo, Cornelius ; Agwe, Samuel M. ; Ankone, Placide A. ; Ngonla, Firmin N.N. ; Mossi, Hans M. ; Etoundi, Alain G.M. ; Eyangoh, Sara I. ; Kazanji, Mirdad ; Njouom, Richard
Description:

During 1979-2022, Cameroon recorded 32 laboratory-confirmed mpox cases among 137 suspected mpox cases identified by the national surveillance network. The highest positivity rate occurred in 2022, indicating potential mpox re-emergence in Cameroon. Both clade I (n = 12) and clade II (n = 18) monkeypox virus (MPXV) were reported, a unique feature of mpox in Cameroon. The overall case-fatality ratio of 2.2% was associated with clade II. We found mpox occurred only in the forested southern part of the country, and MPXV phylogeographic structure revealed a clear geographic separation among concurrent circulating clades. Clade I originated from eastern regions close to neighboring mpox-endemic countries in Central Africa; clade II was prevalent in western regions close to West Africa. Our findings suggest that MPXV re-emerged after a 30-year lapse and might arise from different viral reservoirs unique to ecosystems in eastern and western rainforests of Cameroon.
Subjects:

Ecosystem Humans Monkeypox Virus Mpox (monkeypox)
Keywords:

Cameroon Central Africa Clade I Clade II Concurrent Circulation Epidemiology Forest Geographic Segregation Monkeypox Virus Mpox MPXV Surveillance Surveillance System Viruses West Africa Zoonoses
Source:

Emerg Infect Dis. 2024; 30(3):432-443
Pubmed ID:

38325363
Pubmed Central ID:

PMC10902553
Document Type:

Journal Article
Place as Subject:

Africa, Western ; Cameroon
Volume:

30
Issue:

3
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:cc40c46b1970101acaea245c2fbcc92569c9af4f09ce27abffa55610c50b6d48
Download URL:

https://stacks.cdc.gov/view/cdc/148777/cdc_148777_DS1.pdf
File Type:

[PDF - 2.78 MB ]

File Language:

English

ON THIS PAGE

Details Supporting Files

CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.

As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.