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Concurrent Clade I and Clade II Monkeypox Virus Circulation, Cameroon, 1979–2022
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3 2024
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Source: Emerg Infect Dis. 2024; 30(3):432-443
[PDF-2.78 MB]
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Alternative Title:Emerg Infect Dis
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Description:During 1979-2022, Cameroon recorded 32 laboratory-confirmed mpox cases among 137 suspected mpox cases identified by the national surveillance network. The highest positivity rate occurred in 2022, indicating potential mpox re-emergence in Cameroon. Both clade I (n = 12) and clade II (n = 18) monkeypox virus (MPXV) were reported, a unique feature of mpox in Cameroon. The overall case-fatality ratio of 2.2% was associated with clade II. We found mpox occurred only in the forested southern part of the country, and MPXV phylogeographic structure revealed a clear geographic separation among concurrent circulating clades. Clade I originated from eastern regions close to neighboring mpox-endemic countries in Central Africa; clade II was prevalent in western regions close to West Africa. Our findings suggest that MPXV re-emerged after a 30-year lapse and might arise from different viral reservoirs unique to ecosystems in eastern and western rainforests of Cameroon.
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Pubmed ID:38325363
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Pubmed Central ID:PMC10902553
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Volume:30
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Issue:3
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