Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Schmitt, C. K. ; Meysick, K. C. ; O'Brien, A. D.
Schmitt, C. K. ; Meysick, K. C. ; O'Brien, A. D. Less -
Description:
Many emerging and reemerging bacterial pathogens synthesize toxins that serve as primary virulence factors. We highlight seven bacterial toxins produced by well-established or newly emergent pathogenic microbes. These toxins, which affect eukaryotic cells by a variety of means, include Staphylococcus aureus alpha-toxin, Shiga toxin, cytotoxic necrotizing factor type 1, Escherichia coli heat-stable toxin, botulinum and tetanus neurotoxins, and S. aureus toxic-shock syndrome toxin. For each, we discuss the information available on its synthesis and structure, mode of action, and contribution to virulence. We also review the role certain toxins have played in unraveling signal pathways in eukaryotic cells and summarize the beneficial uses of toxins and toxoids. Our intent is to illustrate the importance of the analysis of bacterial toxins to both basic and applied sciences.
Subject:
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Animals
Bacterial Toxins
Bacterial Vaccines
Botulinum Toxins
Cytotoxins
Enterotoxins
Escherichia Coli Proteins
Humans
Superantigens

Source:
Emerg Infect Dis. 5(2):224-234.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:26fcc53dff9bea8e1df359b38e956e2837b747fb291f512977040ed0798e9e45
File Type:

Supporting Files

• 	10221874.nxml	txt
  	license.txt	txt

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