Details:

• Alternative Title:
  J Head Trauma Rehabil
• Personal Author:
  Hoffman, Jeanne M. ; Ketchum, Jessica M. ; Agtarap, Stephanie ; Dams-O’Connor, Kristen ; Hammond, Flora M. ; ... More +

  Hoffman, Jeanne M. ; Ketchum, Jessica M. ; Agtarap, Stephanie ; Dams-O’Connor, Kristen ; Hammond, Flora M. ; Martin, Aaron M. ; Sevigny, Mitch ; Walker, William C. ; Harrison-Felix, Cynthia ; Zafonte, Ross ; Nakase-Richardson, Risa Less -
• Description:
  Objective:
  
  To define and characterize extreme phenotypes based on pain interference for persons with chronic pain following Traumatic Brain Injury (TBI).
  
  Setting:
  
  18 TBIMS centers.
  
  Participants:
  
  1762 TBIMS participants 1-30 years post-injury (mean age 46.4 years) reporting chronic pain at their most recent follow-up interview.
  
  Primary Measures:
  
  Brief Pain Inventory (BPI) interference scale, sociodemographic, injury, functional outcome, pain, and treatment characteristics.
  
  Results:
  
  Participants were predominantly male (73%), White (75%), middle-aged (mean 46 years), who were injured in motor vehicle accidents (53%) or falls (20%). Extreme phenotypes were identified based on upper and lower 25th percentiles to create low interference (N=441) and high interference (N=431) extreme phenotypes. Bivariate comparisons found several sociodemographic, injury, function, pain, and treatment differences between extreme phenotypes group, including significant differences (p<.001) on all measures of concurrent function with those in the low interference extreme phenotype experiencing better function than those in the high interference extreme phenotype. Lasso regression combined with logistic regression identified multivariable predictors of low vs. high interference extreme phenotypes. Reductions in the odds of low vs. high interference phenotype were significantly associated with higher pain intensity (OR = 0.33), having neuropathic pain (OR = 0.40), migraine headache (OR = 0.41), leg/feet pain (OR = 0.34), or hip pain (OR = 0.46), and more pain catastrophizing (OR = 0.81).
  
  Conclusion:
  
  Results suggest that for those who experience current chronic pain, there is high variability in the experience and impact of pain. Future research is needed to better understand how pain experience impacts individuals with chronic pain and TBI given that pain characteristics were the primary distinguishing factors between phenotypes. The use of extreme phenotypes for pain interference may be useful to better stratify samples to determine efficacy of pain treatment for individuals with TBI.
  
  
• Keywords:
  [+]

  Brain Brain Injuries, Traumatic Chronic Pain Female Humans Male Middle Aged Pain Interference Patient Reported Outcome Phenotype Traumatic Brain Injury
• Source:
  J Head Trauma Rehabil. 39(1):31-42
• Pubmed ID:
  38032832
• Pubmed Central ID:
  PMC10841036
• Document Type:
  Journal Article
• Funding:
  90DPTB0017/ACL/ACL HHSUnited States/ ; U48 DP000033/DP/NCCDPHP CDC HHSUnited States/

  90DPTB0017/ACL/ACL HHSUnited States/ ; U48 DP000033/DP/NCCDPHP CDC HHSUnited States/ Less -
• Volume:
  39
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  [+]

  urn:sha-512:c698350b87977f752f200413025d3c85b17b32cd628df93b75eb6f7acf4c833166a23f092001181cf152e999b68ff7d3c88d8619f62f1562cb0c3dd366c9638e
• File Type:

• Supporting Files:
  No Additional Files