Night shift work, sleep duration and endometrial cancer risk: a pooled analysis from the Epidemiology of Endometrial Cancer Consortium (E2C2)

Details

• Alternative Title:
  Sleep Med Rev
• Personal Author:
  Frias-Gomez, Jon ; Alemany, Laia ; Benavente, Yolanda ; Clarke, Megan A. ; de Francisco, Javier ; De Vivo, Immaculata ; Du, Mengmeng ; Goodman, Marc T. ; Lacey, James ; Liao, Linda M. ; Lipworth, Loren ; Lu, Lingeng ; Merritt, Melissa A. ; Michels, Kara A. ; O’Connell, Kelli ; Paytubi, Sonia ; Pelegrina, Beatriz ; Peremiquel-Trillas, Paula ; Petruzella, Stacey ; Ponce, Jordi ; Risch, Harvey ; Setiawan, Veronica Wendy ; Schouten, Leo J. ; Shu, Xiao-ou ; Trabert, Britton ; Van den Brandt, Piet A. ; Wentzensen, Nicolas ; Wilkens, Lynne R. ; Yu, Herbert ; Costas, Laura
• Description:
  Data on the role of circadian related factors in the etiology of endometrial cancer are scarce. We collected individual data on night shift work or daily sleep duration from 7,207 cases and 22,027 controls participating in 11 studies from the Epidemiology of Endometrial Cancer Consortium (E2C2). Main analyses were performed among postmenopausal women: 6,335 endometrial cancer cases and 18,453 controls. Using individual data, study-specific odd ratios (ORs) and their corresponding 95% confidence intervals (CIs) were estimated with logistic regression and pooled analyses were conducted using random-effects meta-analyses. A non-significant inverse association was observed between endometrial cancer and night shift work (OR=0.89, 95%CI=0.72-1.09; I|=0.0%, P|0.676). Associations did not vary by shift type (permanent or rotating), or duration of night work. Categorizations of short (<7h) or long (≥9h) sleep duration were not associated with endometrial cancer risk (OR|=1.02, 95%CI=0.95-1.10; I|=55.3%, P|=0.022; OR|=0.93, 95%CI=0.81-1.06; I|=11.5%, P|=0.339). No associations were observed per 1-h increment of sleep (OR=0.98, 95%CI=0.95-1.01; I|=46.1%, P|=0.063), but an inverse association was identified among obese women (OR=0.93, 95%CI=0.89-0.98 per 1-h increment; I|=12.7%, P|=0.329). Overall, these pooled analyses provide evidence that night shift work and sleep duration are not strong risk factors for endometrial cancer in postmenopausal women.
• Subjects:
  Endometrial Neoplasms Female Humans Risk Factors Shift Work Schedule Sleep Sleep Duration Work Schedule Tolerance
• Keywords:
  Endometrial Cancer Individual Data Meta-analysis Night Shift Work Pooled Analysis Sleep Duration
• Source:
  Sleep Med Rev. 72:101848
• Pubmed ID:
  37716022
• Pubmed Central ID:
  PMC10840870
• Document Type:
  Journal Article
• Funding:
  K05 CA092002/CA/NCI NIH HHSUnited States/ ; P01 CA087969/CA/NCI NIH HHSUnited States/ ; U01 CA250476/CA/NCI NIH HHSUnited States/ ; R01 CA105212/CA/NCI NIH HHSUnited States/ ; R01 CA047749/CA/NCI NIH HHSUnited States/ ; R01 CA083918/CA/NCI NIH HHSUnited States/ ; P01 CA033619/CA/NCI NIH HHSUnited States/ ; P30 CA033572/CA/NCI NIH HHSUnited States/ ; U01 CA202979/CA/NCI NIH HHSUnited States/ ; N01 HD023166/HD/NICHD NIH HHSUnited States/ ; U01 CA199277/CA/NCI NIH HHSUnited States/ ; UM1 CA164917/CA/NCI NIH HHSUnited States/ ; NU58DP006344/DP/NCCDPHP CDC HHSUnited States/ ; R01 CA087538/CA/NCI NIH HHSUnited States/ ; ZIA CP010126/ImNIH/Intramural NIH HHSUnited States/ ; R01 CA058598/CA/NCI NIH HHSUnited States/ ; R01 CA082838/CA/NCI NIH HHSUnited States/ ; P30 CA008748/CA/NCI NIH HHSUnited States/ ; R03 CA135632/CA/NCI NIH HHSUnited States/ ; P30 CA023100/CA/NCI NIH HHSUnited States/ ; R01 CA098346/CA/NCI NIH HHSUnited States/ ; R01 CA077398/CA/NCI NIH HHSUnited States/ ; P30 CA071789/CA/NCI NIH HHSUnited States/ ; U01 CA164973/CA/NCI NIH HHSUnited States/
• Volume:
  72
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:e523b11f6edecd3f37d6cc492ae731b53ba89d372dfb18ff9f09f63f0cd3dd5cc7bb9668330992d661efac7dd4bbd5e25fd293e0988fdea85d531a9f0e2eeddf
• Download URL:
  https://stacks.cdc.gov/view/cdc/147696/cdc_147696_DS1.pdf
• File Type:
  [PDF - 1.30 MB ]