Two-year follow-up of exposure, engineering controls, respiratory protection and respiratory health among workers at an indium-tin oxide (ITO) production and reclamation facility

Details

• Alternative Title:
  Occup Environ Med
• Personal Author:
  Harvey, R Reid ; Virji, M Abbas ; Blackley, Brie H ; Stanton, Marcia L ; Trapnell, Bruce C ; Carey, Brenna ; Healey, Terrance ; Cummings, Kristin J
• Description:
  Objectives
  
  To determine whether engineering controls and respiratory protection had measurable short-term impact on indium exposure and respiratory health among current indium-tin oxide production and reclamation facility workers.
  
  Methods
  
  We documented engineering controls implemented following our 2012 evaluation and recorded respirator use in 2012 and 2014. We measured respirable indium (Inresp) and plasma indium (InP) in 2012 and 2014, and calculated change in Inresp (ΔInresp) and InP (ΔInP) by the 13 departments. We assessed symptoms, lung function, serum biomarkers of interstitial lung disease (Krebs von den Lungen (KL)-6 and surfactant protein (SP)-D) and chest high-resolution CT at both time points and evaluated workers who participated in both 2012 and 2014 for changes in health outcomes (new, worsened or improved).
  
  Results
  
  Engineering controls included installation of local exhaust ventilation in both grinding departments (Rotary and Planar) and isolation of the Reclaim department. Respiratory protection increased in most (77%) departments. ΔInP and ΔInresp often changed in parallel by department. Among 62 workers participating in both 2012 and 2014, 18 (29%) had new or worsening chest symptoms and 2 (3%) had functional decline in lung function or radiographic progression, but average KL-6 and SP-D concentrations decreased, and no cases of clinical indium lung disease were recognised.
  
  Conclusions
  
  Increased engineering controls and respiratory protection can lead to decreased Inresp, InP and biomarkers of interstitial lung disease among workers in 2 years. Ongoing medical monitoring of indium-exposed workers to confirm the longer-term effectiveness of preventive measures is warranted.
  
  
• Subjects:
  Biomarkers Follow-Up Studies Humans Indium Lung Diseases, Interstitial Occupational Exposure Pulmonary Surfactant-Associated Protein D Tin Compounds
• Source:
  Occup Environ Med. 79(8):550-556
• Pubmed ID:
  35414568
• Pubmed Central ID:
  PMC10823493
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  79
• Issue:
  8
• NIOSHTIC Number:
  nn:20064977
• Collection(s):
  CDC Public Access National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:40849f7744648f5fe4db5a86ba7e1ace1b4631e7fe86ca9d0b2b16de9a46f006982e8d5484883792df1eb54f52cf382ca8002910ce23f2d1528c980c98d8312d
• Download URL:
  https://stacks.cdc.gov/view/cdc/147659/cdc_147659_DS1.pdf
• File Type:
  [PDF - 683.00 KB ]