Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
MacDougall, Conan; Harpe, Spencer E.; Powell, J. Patrick; Johnson, Christopher K.; Edmond, Michael B.; ... More +
MacDougall, Conan; Harpe, Spencer E.; Powell, J. Patrick; Johnson, Christopher K.; Edmond, Michael B.; Polk, Ron E.; Less -
Description:
Few long-term multicenter investigations have evaluated the relationships between aggregate antimicrobial drug use in hospitals and bacterial resistance. We measured fluoroquinolone use from 1999 through 2003 in a network of US hospitals. The percentages of fluoroquinolone-resistant Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus (MRSA) were obtained from yearly antibiograms at each hospital. Univariate linear regression showed significant associations between a hospital's volume of fluoroquinolone use and percent resistance in most individual study years (1999-2001 for P. aeruginosa, 1999-2002 for S. aureus). When the method of generalized estimating equations was used, a population-averaged longitudinal model incorporating total fluoroquinolone use and the previous year's resistance (to account for autocorrelation) did not show a significant effect of fluoroquinolone use on percent resistance for most drug-organism combinations, except for the relationship between levofloxacin use and percent MRSA. The ecologic relationship between fluoroquinolone use and resistance is complex and requires further study.
Subject:
[+]
Cross Infection
Drug Resistance, Multiple, Bacterial
Fluoroquinolones
Humans
Linear Models
Longitudinal Studies
Pseudomonas Infections
Retrospective Studies
Staphylococcal Infections

Source:
Emerg Infect Dis. 11(8):1197-1210.;
Document Type:
Journal Article;
Place as Subject:
United States;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:b938f381f38618bd8b564a4148e72e4dbb4a2d16f0733d7e815be42dbed7f805
File Type:

Supporting Files

• 	05-0116-F1.gif	gif
  	05-0116-F1.jpg	jpeg
  	05-0116-F2.gif	gif
  	05-0116-F2.jpg	jpeg
  	05-0116.nxml	txt
  	license.txt	txt

More +