Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
MacDougall, Conan ; Harpe, Spencer E. ; Powell, J. Patrick ; Johnson, Christopher K. ; Edmond, Michael B. ; ... More +
MacDougall, Conan ; Harpe, Spencer E. ; Powell, J. Patrick ; Johnson, Christopher K. ; Edmond, Michael B. ; Polk, Ron E. Less -
Description:
Few long-term multicenter investigations have evaluated the relationships between aggregate antimicrobial drug use in hospitals and bacterial resistance. We measured fluoroquinolone use from 1999 through 2003 in a network of US hospitals. The percentages of fluoroquinolone-resistant Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus (MRSA) were obtained from yearly antibiograms at each hospital. Univariate linear regression showed significant associations between a hospital's volume of fluoroquinolone use and percent resistance in most individual study years (1999-2001 for P. aeruginosa, 1999-2002 for S. aureus). When the method of generalized estimating equations was used, a population-averaged longitudinal model incorporating total fluoroquinolone use and the previous year's resistance (to account for autocorrelation) did not show a significant effect of fluoroquinolone use on percent resistance for most drug-organism combinations, except for the relationship between levofloxacin use and percent MRSA. The ecologic relationship between fluoroquinolone use and resistance is complex and requires further study.
Subject:
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Cross Infection
Drug Resistance, Multiple, Bacterial
Fluoroquinolones
Humans
Linear Models
Longitudinal Studies
Pseudomonas Infections
Retrospective Studies
Staphylococcal Infections

Source:
Emerg Infect Dis. 11(8):1197-1210.
Document Type:
Journal Article
Place as Subject:
United States
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:b938f381f38618bd8b564a4148e72e4dbb4a2d16f0733d7e815be42dbed7f805
File Type:

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