Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Vasconcelos, Pedro F.C. ; Bryant, Juliet E. ; Travassos da Rosa, Amelia P.A. ; Tesh, Robert B. ; Rodrigues, Sueli G. ; ... More +
Vasconcelos, Pedro F.C. ; Bryant, Juliet E. ; Travassos da Rosa, Amelia P.A. ; Tesh, Robert B. ; Rodrigues, Sueli G. ; Barrett, Alan D.T. Less -
Description:
An analysis of 79 yellow fever virus (YFV) isolates collected from 1935 to 2001 in Brazil showed a single genotype (South America I) circulating in the country, with the exception of a single strain from Rondonia, which represented South America genotype II. Brazilian YFV strains have diverged into two clades; an older clade appears to have become extinct and another has become the dominant lineage in recent years. Pairwise nucleotide diversity between strains ranged from 0% to 7.4%, while amino acid divergence ranged from 0% to 4.6%. Phylogenetic analysis indicated traffic of virus variants through large geographic areas and suggested that migration of infected people may be an important mechanism of virus dispersal. Isolation of vaccine virus from a patient with a fatal case suggests that vaccine-related illness may have been misdiagnosed in the past.
Subjects:
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Amino Acid Sequence Evolution, Molecular Genetic Variation Humans Molecular Epidemiology Phylogeny Research Sequence Alignment Yellow Fever Yellow Fever Virus
Source:
Emerg Infect Dis. 10(9):1578-1584.
Document Type:
Journal Article
Place as Subject:
Brazil
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:3a98dcc798d27bf693f02fdaf526edbb7b44a132c8d0b8a6bd361b5c1b47fddf
Download URL:
https://stacks.cdc.gov/view/cdc/14623/cdc_14623_DS1.pdf
File Type:

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