Viral Loads in Clinical Specimens and SARS Manifestations

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Hung, I.F.N. ; Cheng, V.C.C. ; Wu, A.K.L. ; Tang, B.S.F. ; Chan, K.H. ; Chu, C.M. ; Wong, M.M.L. ; Hui, W.T. ; Poon, L.L.M. ; Tse, D.M.W. ; Chan, K.S. ; Woo, P.C.Y. ; Lau, S.K.P. ; Peiris, J.S.M. ; Yuen, K.Y.
• Description:
  A retrospective viral load study was performed on clinical specimens from 154 patients with laboratory-confirmed severe acute respiratory syndrome (SARS); the specimens were prospectively collected during patients' illness. Viral load in nasopharyngeal aspirates (n = 142) from day 10 to day 15 after onset of symptoms was associated with oxygen desaturation, mechanical ventilation, diarrhea, hepatic dysfunction, and death. Serum viral load (n = 53) was associated with oxygen desaturation, mechanical ventilation, and death. Stool viral load (n = 94) was associated with diarrhea, and urine viral load (n = 111) was associated with abnormal urinalysis results. Viral replications at different sites are important in the pathogenesis of clinical and laboratory abnormalities of SARS.
• Subjects:
  Adult Aged Aged, 80 And Over Disease Outbreaks Feces Female Humans Male Middle Aged Nasopharynx SARS Virus Severe Acute Respiratory Syndrome Viral Load

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• Source:
  Emerg Infect Dis. 10(9):1550-1557.
• Document Type:
  Journal Article
• Volume:
  10
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:bb5a13b3d43cb38453b2d964c63e43771ea4044c8d0c0ad6a5aefb6914d5f999
• Download URL:
  https://stacks.cdc.gov/view/cdc/14594/cdc_14594_DS1.pdf
• File Type:
  [PDF - 194.68 KB ]