Correlating Epidemiologic Trends with the Genotypes Causing Meningococcal Disease, Maryland

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  McEllistrem, M. Catherine ; Kolano, John A. ; Pass, Margaret A. ; Caugant, Dominique A. ; Mendelsohn, Aaron B. ; Pacheco, Antonio Guilherme Fonseca ; Razeq, Jafar ; Harrison, Lee H.
• Corporate Authors:
  Maryland Emerging Infections Program
• Description:
  Epidemic meningococcal infection is generally caused by single clones; whether nonepidemic increases in infection are clonal is unknown. We studied the molecular epidemiology of meningococcal infection during a period that the incidence increased in two age groups. Serogroup C and Y meningococcal isolates were analyzed by pulsed-field gel electrophoresis and multilocus sequence typing. From 1992 to 1999, 96.4% (27/28) of serogroup C isolates from persons 15-24 years of age were in clonal group 1, compared with 65.6% (21/32) of isolates from persons < or =14 years, and 64.3% (9/14) of isolates from adults > or =25 years (p < or = 0.01). The proportion of clonal group 2 serogroup Y strains increased from 7.7% (1/13) in 1992 to 1993 to 52.0% (13/25) in 1998 to 1999 (p < 0.01). The nonepidemic age-specific increases in serogroup C meningococcal infection in Maryland were clonal in nature and the changes in serogroup Y incidence were associated with a shift in the genotypes of strains causing invasive disease.
• Subjects:
  Adolescent Adult Age Distribution Child Child, Preschool Electrophoresis, Gel, Pulsed-Field Genotype Humans Incidence Meningitis, Meningococcal Molecular Epidemiology Population Surveillance Serotyping

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• Source:
  Emerg Infect Dis. 10(3):451-456.
• Document Type:
  Journal Article
• Funding:
  K23 AI 01788/AI/NIAID NIH HHS/United States ; K24 AI 52788/AI/NIAID NIH HHS/United States ; K24 AI052788-09/AI/NIAID NIH HHS/United States ; K24 AI052788-10/AI/NIAID NIH HHS/United States
• Name as Subject:
  Centers for Disease Control and Prevention (US) ; Centers for Disease Control and Prevention (US)
• Place as Subject:
  Maryland
• Location:
  North America
• Volume:
  10
• Issue:
  3
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:8bf3e89ab6437b7acb89e31689e34fb0c007a61aebb9225211c9d82e98ce660f
• Download URL:
  https://stacks.cdc.gov/view/cdc/14132/cdc_14132_DS1.pdf
• File Type:
  [PDF - 259.00 KB ]