i
Correlating Epidemiologic Trends with the Genotypes Causing Meningococcal Disease, Maryland
-
Mar 2004
-
-
Source: Emerg Infect Dis. 10(3):451-456.
[PDF-259.00 KB]
Details:
-
Alternative Title:Emerg Infect Dis
-
Personal Author:
-
Corporate Authors:
-
Description:Epidemic meningococcal infection is generally caused by single clones; whether nonepidemic increases in infection are clonal is unknown. We studied the molecular epidemiology of meningococcal infection during a period that the incidence increased in two age groups. Serogroup C and Y meningococcal isolates were analyzed by pulsed-field gel electrophoresis and multilocus sequence typing. From 1992 to 1999, 96.4% (27/28) of serogroup C isolates from persons 15-24 years of age were in clonal group 1, compared with 65.6% (21/32) of isolates from persons < or =14 years, and 64.3% (9/14) of isolates from adults > or =25 years (p < or = 0.01). The proportion of clonal group 2 serogroup Y strains increased from 7.7% (1/13) in 1992 to 1993 to 52.0% (13/25) in 1998 to 1999 (p < 0.01). The nonepidemic age-specific increases in serogroup C meningococcal infection in Maryland were clonal in nature and the changes in serogroup Y incidence were associated with a shift in the genotypes of strains causing invasive disease.
-
Subjects:
-
Source:
-
Document Type:
-
Funding:
-
Name as Subject:
-
Place as Subject:
-
Location:
-
Volume:10
-
Issue:3
-
Collection(s):
-
Main Document Checksum:
-
Download URL:
-
File Type:
