Doxycycline Prophylaxis for Skin and Soft Tissue Infections in Naval Special Warfare Trainees, United States1

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Spiro, Jeffrey ; Wisniewski, Piotr ; Schwartz, Julia ; Smith, Alfred G. ; Burger, Sara ; Tilley, Drake H. ; Maves, Ryan C.
• Description:
  In 2015, several severe cases of skin and soft tissue infection (SSTI) among US Naval Special Warfare trainees prompted the introduction of doxycycline prophylaxis during the highest-risk portion of training, Hell Week. We performed a retrospective analysis of the effect of this intervention on SSTI incidence and resulting hospital admissions during 2013-2020. In total, 3,371 trainees underwent Hell Week training during the study period; 284 SSTIs were diagnosed overall, 29 of which led to hospitalization. After doxycycline prophylaxis was introduced, admission rates for SSTI decreased from 1.37 to 0.64 admissions/100 trainees (p = 0.036). Overall SSTI rates remained stable at 7.42 to 8.86 SSTIs/100 trainees (p = 0.185). Hospitalization rates per diagnosed SSTI decreased from 18.4% to 7.2% (p = 0.009). Average length of hospitalization decreased from 9.01 days to 4.33 days (p = 0.034). Doxycycline prophylaxis was associated with decreased frequency and severity of hospitalization for SSTIs among this population.
• Subjects:
  Doxycycline Hospitalization Humans Retrospective Studies Skin Soft Tissue Infections
• Keywords:
  Bacteria Doxycycline Military Prophylaxis Saltwater Exposure Skin And Soft Tissue Infection SSTI
• Source:
  Emerg Infect Dis. 2024; 30(1):89-95
• Pubmed ID:
  38146981
• Pubmed Central ID:
  PMC10756378
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Volume:
  30
• Issue:
  1
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:48c28f1a6dba663067f2309dd662543127eb64a27421ea1a7882309ce5d58a14
• Download URL:
  https://stacks.cdc.gov/view/cdc/140576/cdc_140576_DS1.pdf
• File Type:
  [PDF - 503.78 KB ]