Highly Pathogenic Avian Influenza A(H5N1) Virus Clade 2.3.4.4b Infections in Wild Terrestrial Mammals, United States, 2022

Elsmo, Elizabeth J.; Wünschmann, Arno; Beckmen, Kimberlee B.; Broughton-Neiswanger, Liam E.; Buckles, Elizabeth L.; Ellis, Jayne; Fitzgerald, Scott D.; Gerlach, Robert; Hawkins, Shawna; Ip, Hon S.; Lankton, Julia S.; Lemley, Erin M.; Lenoch, Julianna B.; Killian, Mary L.; Lantz, Kristina; Long, Lindsey; Maes, Roger; Mainenti, Marta; Melotti, Julie; Moriarty, Megan E.; Nakagun, Shotaro; Ruden, Rachel M.; Shearn-Bochsler, Valerie; Thompson, Danielle; Torchetti, Mia K.; Van Wettere, Arnaud J.; Wise, Annabel G.; Lim, Ailam L.

doi:10.3201/eid2912.230464

i

Highly Pathogenic Avian Influenza A(H5N1) Virus Clade 2.3.4.4b Infections in Wild Terrestrial Mammals, United States, 2022

Supporting Files Public Domain

12 2023
By Elsmo, Elizabeth J. ; Wünschmann, Arno ; Beckmen, Kimberlee B. ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Elsmo, Elizabeth J. ; Wünschmann, Arno ; Beckmen, Kimberlee B. ; Broughton-Neiswanger, Liam E. ; Buckles, Elizabeth L. ; Ellis, Jayne ; Fitzgerald, Scott D. ; Gerlach, Robert ; Hawkins, Shawna ; Ip, Hon S. ; Lankton, Julia S. ; Lemley, Erin M. ; Lenoch, Julianna B. ; Killian, Mary L. ; Lantz, Kristina ; Long, Lindsey ; Maes, Roger ; Mainenti, Marta ; Melotti, Julie ; Moriarty, Megan E. ; Nakagun, Shotaro ; Ruden, Rachel M. ; Shearn-Bochsler, Valerie ; Thompson, Danielle ; Torchetti, Mia K. ; Van Wettere, Arnaud J. ; Wise, Annabel G. ; Lim, Ailam L.
Description:

We describe the pathology of natural infection with highly pathogenic avian influenza A(H5N1) virus of Eurasian lineage Goose/Guangdong clade 2.3.4.4b in 67 wild terrestrial mammals throughout the United States during April 1‒July 21, 2022. Affected mammals include 50 red foxes (Vulpes vulpes), 6 striped skunks (Mephitis mephitis), 4 raccoons (Procyon lotor), 2 bobcats (Lynx rufus), 2 Virginia opossums (Didelphis virginiana), 1 coyote (Canis latrans), 1 fisher (Pekania pennanti), and 1 gray fox (Urocyon cinereoargenteus). Infected mammals showed primarily neurologic signs. Necrotizing meningoencephalitis, interstitial pneumonia, and myocardial necrosis were the most common lesions; however, species variations in lesion distribution were observed. Genotype analysis of sequences from 48 animals indicates that these cases represent spillover infections from wild birds.
Subjects:

Highly Pathogenic Avian Influenza A(H5N1) Virus Clade 2.3.4.4b Infections In Wild Terrestrial Mammals, United States, 2022 Research
Keywords:

Animals Animals, Wild Avian Influenza Bobcat Clade 2.3.4.4b Coyote Fisher Fox Foxes Highly Pathogenic Avian Influenza Virus Influenza Influenza A(H5N1) Influenza A Virus, H5N1 Subtype Influenza In Birds Mammals Meningitis/Encephalitis Mephitidae Opossum Raccoon Respiratory Infections Skunk United States Viruses Wild Terrestrial Mammals Zoonoses
Source:

Emerg Infect Dis. 2023; 29(12):2451-2460
Pubmed ID:

37987580
Pubmed Central ID:

PMC10683806
Document Type:

Journal Article
Volume:

29
Issue:

12
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:6bc97e482b1face2c0cc4447322766bba49ee308b6b0d31a6814f1b74303bfc6
Download URL:

https://stacks.cdc.gov/view/cdc/138515/cdc_138515_DS1.pdf
File Type:

[PDF - 3.68 MB ]

File Language:

English

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