Fatal Human Neurologic Infection Caused by Pigeon Avian Paramyxovirus-1, Australia

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Hurley, Siobhan ; Eden, John Sebastian ; Bingham, John ; Rodriguez, Michael ; Neave, Matthew J. ; Johnson, Alexandra ; Howard-Jones, Annaleise R. ; Kok, Jen ; Anazodo, Antoinette ; McMullan, Brendan ; Williams, David T. ; Watson, James ; Solinas, Annalisa ; Kim, Ki Wook ; Rawlinson, William
• Description:
  Avian paramyxovirus type 1 (APMV-1) is a virus of birds that results in a range of outcomes, from asymptomatic infections to outbreaks of systemic respiratory and neurologic disease, depending on the virus strain and the avian species affected. Humans are rarely affected; those who are predominantly experience mild conjunctivitis. We report a fatal case of neurologic disease in a 2-year-old immunocompromised child in Australia. Metagenomic sequencing and histopathology identified the causative agent as the pigeon variant of APMV-1. This diagnosis should be considered in neurologic conditions of undefined etiologies. Agnostic metagenomic sequencing methods are useful in such settings to direct diagnostic and therapeutic efforts.
• Subjects:
  Fatal Human Neurologic Infection Caused By Pigeon Avian Paramyxovirus-1, Australia Research
• Keywords:
  Animals Australia Avian Paramyxovirus-1 Brain Child, Preschool Columbidae Communicable Diseases Histopathology Humans Metagenomics Newcastle Disease Newcastle Disease Virus Phylogeny Pigeon Paramyxovirus Type 1 Viruses Zoonoses

  More +
• Source:
  Emerg Infect Dis. 2023; 29(12):2482-2487
• Pubmed ID:
  37987582
• Pubmed Central ID:
  PMC10683822
• Document Type:
  Journal Article
• Volume:
  29
• Issue:
  12
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:def5e665237301e5bc73e0f8c05c8c5d35044ee34eaf267030a339a4752fb8f3
• Download URL:
  https://stacks.cdc.gov/view/cdc/138512/cdc_138512_DS1.pdf
• File Type:
  [PDF - 1.74 MB ]