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Fatal Human Neurologic Infection Caused by Pigeon Avian Paramyxovirus-1, Australia
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12 2023
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Source: Emerg Infect Dis. 2023; 29(12):2482-2487
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Alternative Title:Emerg Infect Dis
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Description:Avian paramyxovirus type 1 (APMV-1) is a virus of birds that results in a range of outcomes, from asymptomatic infections to outbreaks of systemic respiratory and neurologic disease, depending on the virus strain and the avian species affected. Humans are rarely affected; those who are predominantly experience mild conjunctivitis. We report a fatal case of neurologic disease in a 2-year-old immunocompromised child in Australia. Metagenomic sequencing and histopathology identified the causative agent as the pigeon variant of APMV-1. This diagnosis should be considered in neurologic conditions of undefined etiologies. Agnostic metagenomic sequencing methods are useful in such settings to direct diagnostic and therapeutic efforts.
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Pubmed ID:37987582
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Pubmed Central ID:PMC10683822
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