First Human Isolate of Hantavirus (Andes virus) in the Americas

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Galeno, Hector ; Mora, Judith ; Villagra, Eliecer ; Fernandez, Jorge ; Hernandez, Jury ; Mertz, Gregory J. ; Ramirez, Eugenio
• Description:
  We isolated Andes virus (formal name: Andes virus [ANDV], a species in the genus Hantavirus), from serum of an asymptomatic 10-year-old Chilean boy who died 6 days later of hantavirus pulmonary syndrome (HPS). The serum was obtained 12 days after his grandmother died from HPS and 2 days before he became febrile. No hantavirus immunoglobulin (Ig) G or IgM antibodies were detected in the serum sample. After three blind passages, ANDV antigens were detected in Vero E6 cells by immunofluorescence assay and enzyme-linked immunosorbent assay, and ANDV RNA was detected by reverse transcription-polymerase chain reaction. A fragment of the virus genome showed 96.2% nucleotide identity with that of prototype ANDV. To our knowledge, this is the first isolation of any agent of hemorrhagic fever with HPS from a human and the first such isolation of hantavirus before symptoms of that syndrome or HPS began.
• Subjects:
  Animals Cercopithecus Aethiops Child Evolution, Molecular Fatal Outcome Female Fluorescent Antibody Technique Hantavirus Infections Humans Male Middle Aged Time Factors Vero Cells

  More +
• Source:
  Emerg Infect Dis. 8(7):657-661.
• Document Type:
  Journal Article
• Place as Subject:
  Chile
• Volume:
  8
• Issue:
  7
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:768d0ac8c95c604aee55c29cd57c5338384f3e99c16cf25a706b486f248d98e0
• Download URL:
  https://stacks.cdc.gov/view/cdc/13812/cdc_13812_DS1.pdf
• File Type:
  [PDF - 1018.28 KB ]