Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Galeno, Hector ; Mora, Judith ; Villagra, Eliecer ; Fernandez, Jorge ; Hernandez, Jury ; ... More +
Galeno, Hector ; Mora, Judith ; Villagra, Eliecer ; Fernandez, Jorge ; Hernandez, Jury ; Mertz, Gregory J. ; Ramirez, Eugenio ; Less -
Description:
We isolated Andes virus (formal name: Andes virus [ANDV], a species in the genus Hantavirus), from serum of an asymptomatic 10-year-old Chilean boy who died 6 days later of hantavirus pulmonary syndrome (HPS). The serum was obtained 12 days after his grandmother died from HPS and 2 days before he became febrile. No hantavirus immunoglobulin (Ig) G or IgM antibodies were detected in the serum sample. After three blind passages, ANDV antigens were detected in Vero E6 cells by immunofluorescence assay and enzyme-linked immunosorbent assay, and ANDV RNA was detected by reverse transcription-polymerase chain reaction. A fragment of the virus genome showed 96.2% nucleotide identity with that of prototype ANDV. To our knowledge, this is the first isolation of any agent of hemorrhagic fever with HPS from a human and the first such isolation of hantavirus before symptoms of that syndrome or HPS began.
Subject:
[+]
Animals
Cercopithecus Aethiops
Child
Evolution, Molecular
Fatal Outcome
Female
Fluorescent Antibody Technique
Hantavirus Infections
Humans
Male
Middle Aged
Time Factors
Vero Cells

Source:
Emerg Infect Dis. 8(7):657-661.
Document Type:
Journal Article ;
Place as Subject:
Chile ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:768d0ac8c95c604aee55c29cd57c5338384f3e99c16cf25a706b486f248d98e0
File Type:

Supporting Files

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