First Human Isolate of Hantavirus (Andes virus) in the Americas

Galeno, Hector; Mora, Judith; Villagra, Eliecer; Fernandez, Jorge; Hernandez, Jury; Mertz, Gregory J.; Ramirez, Eugenio

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First Human Isolate of Hantavirus (Andes virus) in the Americas

Published Date:

Jul 2002

Source:

Emerg Infect Dis. 8(7):657-661.

[PDF-1018.28 KB]

Details:

Alternative Title:

Emerg Infect Dis

Personal Author:

Galeno, Hector ; Mora, Judith ; Villagra, Eliecer ; Fernandez, Jorge ; Hernandez, Jury ; ... More ▼

Description:

We isolated Andes virus (formal name: Andes virus [ANDV], a species in the genus Hantavirus), from serum of an asymptomatic 10-year-old Chilean boy who died 6 days later of hantavirus pulmonary syndrome (HPS). The serum was obtained 12 days after his grandmother died from HPS and 2 days before he became febrile. No hantavirus immunoglobulin (Ig) G or IgM antibodies were detected in the serum sample. After three blind passages, ANDV antigens were detected in Vero E6 cells by immunofluorescence assay and enzyme-linked immunosorbent assay, and ANDV RNA was detected by reverse transcription-polymerase chain reaction. A fragment of the virus genome showed 96.2% nucleotide identity with that of prototype ANDV. To our knowledge, this is the first isolation of any agent of hemorrhagic fever with HPS from a human and the first such isolation of hantavirus before symptoms of that syndrome or HPS began.

Subject:

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Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

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