Pubertal maturation and timing effects on resting state electroencephalography in autistic and comparison youth

Details

• Alternative Title:
  Dev Psychobiol
• Personal Author:
  Rea, Hannah M. ; Clawson, Ann ; Hudac, Caitlin M. ; Santhosh, Megha ; Bernier, Raphael A. ; Earl, Rachel K. ; Pelphrey, Kevin A. ; Webb, Sara Jane ; Neuhaus, Emily
• Corporate Authors:
  GENDAAR Consortium
• Description:
  Autistic and comparison individuals differ in resting-state electroencephalography (EEG), such that sex and age explain variability within and between groups. Pubertal maturation and timing may further explain variation, as previous work has suggested alterations in pubertal timing in autistic youth. In a sample from two studies of 181 autistic and 94 comparison youth (8 years to 17 years and 11 months), mixed-effects linear regressions were conducted to assess differences in EEG (midline power for theta, alpha, and beta frequency bands). Alpha power was analyzed as a mediator in the relation between pubertal maturation and timing with autistic traits in the autistic groups to understand the role of puberty in brain-based changes that contribute to functional outcomes. Individuals advanced in puberty exhibited decreased power in all bands. Those who experienced puberty relatively early showed decreased power in theta and beta bands, controlling for age, sex, and diagnosis. Autistic individuals further along in pubertal development exhibited lower social skills. Alpha mediated the relation between puberty and repetitive behaviors. Pubertal maturation and timing appear to play unique roles in the development of cognitive processes for autistic and comparison youth and should be considered in research on developmental variation in resting-state EEG.
• Subjects:
  Adolescent Autistic Disorder Brain Electroencephalography Humans Puberty Social Skills
• Keywords:
  Autism Spectrum Disorder Electroencephalography (EEG) Pubertal Maturation Pubertal Timing Resting State Spectral Power
• Source:
  Dev Psychobiol. 65(7):e22415
• Pubmed ID:
  37860899
• Pubmed Central ID:
  PMC10713348
• Document Type:
  Journal Article
• Funding:
  R01 MH100047/MH/NIMH NIH HHSUnited States/ ; P50 HD103524/HD/NICHD NIH HHSUnited States/ ; R01 MH10028/NH/NIH HHSUnited States/ ; R01 MH100047/NH/NIH HHSUnited States/ ; R01 MH100028/MH/NIMH NIH HHSUnited States/ ; R01 OH010028/OH/NIOSH CDC HHSUnited States/
• Volume:
  65
• Issue:
  7
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:bbe0e25da4076fbeca16d8c4a0408c52a5ca47965c9ff527f173b028c372090c3ca15fd6b3d471f982628bea67abe78787e0158fcc9d953615218e55ccf578f7
• Download URL:
  https://stacks.cdc.gov/view/cdc/137173/cdc_137173_DS1.pdf
• File Type:
  [PDF - 2.25 MB ]