Association of Gestational Diabetes Mellitus and Perinatal Maternal Depression with Early Childhood Behavioral Problems: An Environmental Influences on Child Health Outcomes (ECHO) Study

Details

• Alternative Title:
  Child Dev
• Personal Author:
  Shuffrey, Lauren C. ; Morales, Santiago ; Jacobson, Melanie H. ; Enlow, Michelle Bosquet ; Ghassabian, Akhgar ; Margolis, Amy E. ; Lucchini, Maristella ; Carroll, Kecia N. ; Crum, Rosa M. ; Dabelea, Dana ; Deutsch, Arielle ; Fifer, William P. ; Goldson, Brandon ; Hockett, Christine W. ; Mason, W. Alex ; Jacobson, Lisette T. ; O’Connor, Thomas G ; Pini, Nicolò ; Rayport, Yael ; Sania, Ayesha ; Trasande, Leonardo ; Wright, Rosalind J. ; Lee, Seonjoo ; Monk, Catherine
• Description:
  This study examined the association of gestational diabetes mellitus (GDM), prenatal, and postnatal maternal depressive symptoms with externalizing, internalizing, and autism spectrum problems on the Preschool Child Behavior Checklist in 2379 children aged 4.12 ± 0.60 (48% female; 47% White, 32% Black, 15% Mixed Race, 4% Asian, <2% American Indian/Alaskan Native, <2% Native Hawaiian; 23% Hispanic). Data were collected from the NIH Environmental influences on Child Health Outcomes (ECHO) Program from 2009-2021. GDM, prenatal, and postnatal maternal depressive symptoms were each associated with increased child externalizing and internalizing problems. GDM was associated with increased autism behaviors only among children exposed to perinatal maternal depressive symptoms above the median level. Stratified analyses revealed a relation between GDM and child outcomes in males only.
• Subjects:
  Child, Preschool Depression Depressive Disorder Diabetes, Gestational Female Humans Male Mothers Outcome Assessment, Health Care Pregnancy
• Source:
  Child Dev. 94(6):1595-1609
• Pubmed ID:
  37132048
• Pubmed Central ID:
  PMC10620104
• Document Type:
  Journal Article
• Funding:
  U24 OD023382/OD/NIH HHSUnited States/ ; UH3 OD023337/CD/ODCDC CDC HHSUnited States/ ; U2C OD023375/OD/NIH HHSUnited States/ ; UH3 OD023279/CD/ODCDC CDC HHSUnited States/ ; UH3 OD023271/OD/NIH HHSUnited States/ ; UH3 OD023248/OD/NIH HHSUnited States/ ; U24 OD023319/OD/NIH HHSUnited States/ ; UH3 OD023305/OD/NIH HHSUnited States/ ; UH3 OD023279/OD/NIH HHSUnited States/ ; UH3 OD023271/CD/ODCDC CDC HHSUnited States/ ; UH3 OD023248/CD/ODCDC CDC HHSUnited States/ ; UH3 OD023349/OD/NIH HHSUnited States/ ; R00 HD103910/HD/NICHD NIH HHSUnited States/ ; UH3 OD023349/CD/ODCDC CDC HHSUnited States/ ; UH3 OD023328/CD/ODCDC CDC HHSUnited States/ ; L40 HD099886/HD/NICHD NIH HHSUnited States/ ; UH3 OD023337/OD/NIH HHSUnited States/ ; UH3 OD023305/CD/ODCDC CDC HHSUnited States/ ; K99 HD103910/HD/NICHD NIH HHSUnited States/ ; UH3 OD023328/OD/NIH HHSUnited States/
• Volume:
  94
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:a7d366e309d0f39df2a714882f898bcf0dd75ccf13804752b241aa3ae42e21f0097fd6aeb53d889791722d7a9c365e98191b83187dfdf35b3ac6b7af8cf94aa2
• Download URL:
  https://stacks.cdc.gov/view/cdc/135027/cdc_135027_DS1.pdf
• File Type:
  [PDF - 942.81 KB ]