Morbidity and Mortality Weekly Report: Recommendations and Reports, August 24, 2001 / Vol. 50 / No. RR-15

Details

• Alternative Title:
  U.S. Public Health Service Guideline on Infectious Disease Issues in Xenotransplantation
• Journal Article:
  Morbidity and Mortality Weekly Report (MMWR): Recommendations and Reports
• Corporate Authors:
  Center for Biologics Evaluation and Research (U.S.) ; Centers for Diseases Control and Prevention (U.S.) ; National Center for Infectious Diseases (U.S.) ; United States, Department of Health, Education, and Welfare., Office of the Assistant Secretary for Planning and Evaluation ; United States, Health Resources and Services Administration.
• Description:
  Several developments have fueled the renewed interest in xenotransplantation — the use of live animal cells, tissues and organs in the treatment or mitigation of human disease. The world-wide, critical shortage of human organs available for transplantation and advances in genetic engineering and in the immunology and biology of organ/tissue rejection have renewed scientists’ interest in investigating xenotransplantation as a potentially promising means to treat a wide range of human disorders. This situation is highlighted by the fact that in the United States alone, 13 patients die each day waiting to receive a life-saving transplant to replace a diseased vital organ.
  
  While animal organs are proposed as an investigational alternative to human organ transplantation, xenotransplantation is also being used in the effort to treat diseases for which human organ allotransplants are not traditional therapies (e.g., epilepsy, chronic intractable pain syndromes, insulin dependent diabetes mellitus and degenerative neurologic diseases such as Parkinson’s disease and Huntington’s disease). At present, the majority of clinical xenotransplantation procedures utilize avascular cells or tissues rather than solid organs in large part due to the immunologic barriers that the human host presents to vascularized xenotransplantation products. However, with recent scientific advances, xenotransplantation is viewed by many researchers as having the potential for treating not only end-organ failure but also chronic debilitating diseases that affect major segments of the world population.
  
  Although the potential benefits may be considerable, the use of xenotransplantation also presents a number of significant challenges. These include (1) the potential risk of transmission of infectious agents from source animals to patients, their close contacts, and the general public; (2) the complexities of informed consent; and (3) animal welfare issues
  
  
• Subjects:
  Animals Communicable Disease Control / Standards Communicable Diseases / Transmission Transplantation, Heterologous / Adverse Effects
• Source:
  Morbidity and Mortality Weekly Report (MMWR): Recommendations and Reports, 2001; v. 50, no. 15
• Series:
  Recommendations and Reports: Morbidity and Mortality Weekly Report (MMWR)
• ISSN:
  1057-5987 (print) ; 1545-8601 (digital)
• Pubmed ID:
  11534745
• Document Type:
  Journal Issue
• Genre:
  Guideline
• Pages in Document:
  56 pdf pages
• Volume:
  50
• Issue:
  15
• Collection(s):
  Guidelines and Recommendations Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:8eba2167fb3fc20a39866b48da1ccf4a6436c2034a7d57ba01302d61c8be9eb6df718bbd348436fdbc9e16be826a846864cc64822a99683ea1c74aa09575f6b6
• Download URL:
  https://stacks.cdc.gov/view/cdc/13482/cdc_13482_DS1.pdf
• File Type:
  [PDF - 256.27 KB ]