Technical Report : Highly Pathogenic Avian Influenza A(H5N1) Viruses
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Technical Report : Highly Pathogenic Avian Influenza A(H5N1) Viruses

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  • Corporate Authors:
    National Center for Immunization and Respiratory Diseases (U.S.)
  • Description:
    cdc:130752

    Updated October 27, 2023

    This report provides an update to the original report posted on March 17, 2023, to include additional sporadic human cases and activity in wild birds, poultry, and other animals. The overall risk to human health associated with the ongoing outbreaks of highly pathogenic avian influenza A(H5N1) viruses in wild birds and poultry has not changed and remains low at this time.

    A small number of sporadic human cases of A(H5N1) have been identified since 2022, despite the panzootic of highly pathogenic avian influenza (HPAI) A(H5N1) viruses in wild birds and poultry. Nearly all reported human cases since 2022 were associated with poultry exposures, and no cases of mammal-to-human or human-to-human transmission of HPAI A(H5N1) virus have been identified. In a few cases, the source of exposure to HPAI A(H5N1) virus was unknown. To date, HPAI A(H5N1) viruses currently circulating in birds and poultry, with spillover to mammals, and those that have caused human infections do not have the ability to easily bind to receptors that predominate in the human upper respiratory tract. Therefore, the current risk to the public from HPAI A(H5N1) viruses remains low. However, because of the potential for influenza viruses to rapidly evolve and the wide global prevalence of HPAI A(H5N1) viruses in wild birds and poultry outbreaks, continued sporadic human infections are anticipated. Continued comprehensive surveillance of these viruses in wild birds, poultry, mammals, and people worldwide, and frequent reassessments are critical to determine the public health risk, along with ongoing preparedness efforts.

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  • Place as Subject:
    United States
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