Incidence, Prevalence and Racial and Ethnic Distribution of Inflammatory Bowel Disease in the United States

Details

• Alternative Title:
  Gastroenterology
• Personal Author:
  Lewis, James D. ; Parlett, Lauren E. ; Jonsson-Funk, Michele L. ; Brensinger, Colleen ; Pate, Virginia ; Wu, Qufei ; Dawwas, Ghadeer K. ; Weiss, Alexandra ; Constant, Brad D. ; McCauley, Maureen ; Haynes, Kevin ; Yang, Jeff Yufeng ; Schaubel, Douglas E. ; Hurtado-Lorenzo, Andres ; Kappelman, Michael David
• Description:
  Background & Aims:
  
  We sought to estimate the incidence, prevalence and racial-ethnic distribution of physician-diagnosed inflammatory bowel disease (IBD) in the United States.
  
  Methods:
  
  The study utilized four administrative claims datasets: a 20% random sample of national fee for service Medicare data (2007 to 2017); Medicaid data from Florida, New York, Pennsylvania, Ohio and California (1999 to 2012); and commercial health insurance data from Anthem beneficiaries (2006 to 2018) and Optum’s de-identified Clinformatics Data Mart (2000 to 2017). We used validated combinations of medical diagnoses, diagnostic procedures and prescription medications to identify incident and prevalent diagnoses. We computed pooled age-, sex- and race-specific insurance-weighted estimates and pooled estimates standardized to 2018 United States census estimates with 95% confidence intervals (CI).
  
  Results:
  
  The age- and sex-standardized incidence of IBD per 100,000 person-years was 10.9 (95% CI 10.6 – 11.2). The incidence of IBD peaked in the third decade of life, decreased to a relatively stable level across the 4th to 8th decades, and declined further. The age-, sex- and insurance-standardized prevalence of IBD was 721 per 100,000 population (95% CI 717 – 726). Extrapolated to the 2020 census, there is an estimated 2.39 million Americans diagnosed with IBD. The prevalence of IBD per 100,000 population was 812 (95% CI 802 – 823) in White, 504 (482–526) in Black, 403 (373 – 433) in Asian and 458 (440–476) in Hispanic Americans.
  
  Conclusions:
  
  IBD is diagnosed in more than 0.7% of Americans. The incidence peaks in early adulthood and then plateaus at a lower rate. The disease is less commonly diagnosed in Black, Asian and Hispanic Americans.
  
  
• Subjects:
  Adult Aged Florida Humans Incidence Inflammatory Bowel Diseases Medicare Prevalence United States
• Keywords:
  Crohn’s Disease Epidemiology Medicaid Race Ulcerative Colitis
• Source:
  Gastroenterology. 165(5):1197-1205.e2
• Pubmed ID:
  37481117
• Pubmed Central ID:
  PMC10592313
• Document Type:
  Journal Article
• Funding:
  P30 DK050306/DK/NIDDK NIH HHSUnited States/ ; U01 DP006369/DP/NCCDPHP CDC HHSUnited States/ ; UL1 TR002489/TR/NCATS NIH HHSUnited States/ ; UM1 TR004406/TR/NCATS NIH HHSUnited States/
• Volume:
  165
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:8c1a7f9ef2d4ddbde0e31461e7814f5d6b859b1085e234dc3a42b1b98484a3bda84aaaf07ca388198f72908dcd87f9f0786eac0734426a49b07f59ae0fcdda9a
• Download URL:
  https://stacks.cdc.gov/view/cdc/134534/cdc_134534_DS1.pdf
• File Type:
  [PDF - 728.28 KB ]