No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels

Details

• Alternative Title:
  Diabetes
• Personal Author:
  Scott, Robert A. ; Chu, Audrey Y. ; Grarup, Niels ; Manning, Alisa K. ; Hivert, Marie-France ; Shungin, Dmitry ; Tönjes, Anke ; Yesupriya, Ajay ; Barnes, Daniel ; Bouatia-Naji, Nabila ; Glazer, Nicole L. ; Jackson, Anne U. ; Kutalik, Zoltán ; Lagou, Vasiliki ; Marek, Diana ; Rasmussen-Torvik, Laura J. ; Stringham, Heather M. ; Tanaka, Toshiko ; Aadahl, Mette ; Arking, Dan E. ; Bergmann, Sven ; Boerwinkle, Eric ; Bonnycastle, Lori L. ; Bornstein, Stefan R. ; Brunner, Eric ; Bumpstead, Suzannah J. ; Brage, Soren ; Carlson, Olga D. ; Chen, Han ; Chen, Yii-Der Ida ; Chines, Peter S. ; Collins, Francis S. ; Couper, David J. ; Dennison, Elaine M. ; Dowling, Nicole F. ; Egan, Josephine S. ; Ekelund, Ulf ; Erdos, Michael R. ; Forouhi, Nita G. ; Fox, Caroline S. ; Goodarzi, Mark O. ; Grässler, Jürgen ; Gustafsson, Stefan ; Hallmans, Göran ; Hansen, Torben ; Hingorani, Aroon ; Holloway, John W. ; Hu, Frank B. ; Isomaa, Bo ; Jameson, Karen A. ; Johansson, Ingegerd ; Jonsson, Anna ; Jørgensen, Torben ; Kivimaki, Mika ; Kovacs, Peter ; Kumari, Meena ; Kuusisto, Johanna ; Laakso, Markku ; Lecoeur, Cécile ; Lévy-Marchal, Claire ; Li, Guo ; Loos, Ruth J.F. ; Lyssenko, Valeri ; Marmot, Michael ; Marques-Vidal, Pedro ; Morken, Mario A. ; Müller, Gabriele ; North, Kari E. ; Pankow, James S. ; Payne, Felicity ; Prokopenko, Inga ; Psaty, Bruce M. ; Renström, Frida ; Rice, Ken ; Rotter, Jerome I. ; Rybin, Denis ; Sandholt, Camilla H. ; Sayer, Avan A. ; Shrader, Peter ; Schwarz, Peter E.H. ; Siscovick, David S. ; Stančáková, Alena ; Stumvoll, Michael ; Teslovich, Tanya M. ; Waeber, Gérard ; Williams, Gordon H. ; Witte, Daniel R. ; Wood, Andrew R. ; Xie, Weijia ; Boehnke, Michael ; Cooper, Cyrus ; Ferrucci, Luigi ; Froguel, Philippe ; Groop, Leif ; Kao, W.H. Linda ; Vollenweider, Peter ; Walker, Mark ; Watanabe, Richard M. ; Pedersen, Oluf ; Meigs, James B. ; Ingelsson, Erik ; Barroso, Inês ; Florez, Jose C. ; Franks, Paul W. ; Dupuis, Josée ; Wareham, Nicholas J. ; Langenberg, Claudia
• Description:
  Gene-lifestyle interactions have been suggested to contribute to the development of type 2 diabetes. Glucose levels 2 h after a standard 75-g glucose challenge are used to diagnose diabetes and are associated with both genetic and lifestyle factors. However, whether these factors interact to determine 2-h glucose levels is unknown. We meta-analyzed single nucleotide polymorphism (SNP) × BMI and SNP × physical activity (PA) interaction regression models for five SNPs previously associated with 2-h glucose levels from up to 22 studies comprising 54,884 individuals without diabetes. PA levels were dichotomized, with individuals below the first quintile classified as inactive (20%) and the remainder as active (80%). BMI was considered a continuous trait. Inactive individuals had higher 2-h glucose levels than active individuals (β = 0.22 mmol/L [95% CI 0.13-0.31], P = 1.63 × 10(-6)). All SNPs were associated with 2-h glucose (β = 0.06-0.12 mmol/allele, P ≤ 1.53 × 10(-7)), but no significant interactions were found with PA (P > 0.18) or BMI (P ≥ 0.04). In this large study of gene-lifestyle interaction, we observed no interactions between genetic and lifestyle factors, both of which were associated with 2-h glucose. It is perhaps unlikely that top loci from genome-wide association studies will exhibit strong subgroup-specific effects, and may not, therefore, make the best candidates for the study of interactions.
• Subjects:
  Blood Glucose Body Mass Index Epigenesis, Genetic Gene Expression Regulation Genetics/Genomes/Proteomics/Metabolomics Genotype Humans Life Style Motor Activity Polymorphism, Single Nucleotide
• Source:
  Diabetes. 2012; 61(5):1291-1296.
• Document Type:
  Journal Article
• Volume:
  61
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:dafbd414163067bee35ec2c1261eae8f8a9fa9b6fa833257ac829ea8a5081e95
• Download URL:
  https://stacks.cdc.gov/view/cdc/13434/cdc_13434_DS1.pdf
• File Type:
  [PDF - 150.94 KB ]