Ambient Air Quality and Fatal Asthma Exacerbations among Children in North Carolina

Details

• Journal Article:
  Epidemiology
• Personal Author:
  Mirabelli, Maria C. ; Flanders, W. Dana ; Vaidyanathan, Ambarish ; Beavers, Daniel P. ; Gower, W. Adam
• Description:
  Background:
  
  Little is known about the role of air quality in fatal asthma exacerbations among children.
  
  Methods:
  
  We collected information about 80 deaths that occurred in North Carolina from 2001 through 2016, among children aged 5-17 years, with asthma identified as the primary cause of death. We linked information about each death with county-level estimates of particulate matter ≤2.5 μm (PM2.5) and ozone (O3). Using the linked data, we conducted a case-crossover analysis of associations between PM2.5 and O3 lagged by 3-5 days with the odds of fatal asthma exacerbations.
  
  Results:
  
  In the highest tertile of PM2.5 lag(3-5), the odds of a fatal exacerbation of asthma were more than twice the odds in the lowest tertile (odds ratio = 2.2; 95% confidence interval = 1.1, 4.6).
  
  Conclusion:
  
  These findings from North Carolina provide evidence to support the hypothesis that ambient air pollution increases the risk of fatal exacerbations of asthma among children.
• Subjects:
  • Child
  • Humans
  • North Carolina
  • Air Pollution
  • Asthma
  • Ozone
  • Particulate Matter
• Keywords:
  • Air pollution
  • Asthma
  • Child
  • Epidemiology
  • Mortality
• Source:
  Epidemiology. 34(6):888-891
• Pubmed ID:
  37757877
• Pubmed Central ID:
  PMC10542867
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  34
• Issue:
  6
• Download URL:
  https://stacks.cdc.gov/view/cdc/133830/cdc_133830_DS1.pdf
• File Type:
  [PDF - 82.59 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:53b956d546b0419c100ae70a96f68887c2e2172d71719fdf6f91b7c2dfba65ab829166b374f0b66a30610a733816c362afb9123849fd4057a52d928d76454c3f