Morbidity and Mortality Weekly Report: Recommendations and Reports, December 12, 1997 / Vol. 46 / No. RR-16

Details

• Alternative Title:
  Newborn Screening for Cystic Fibrosis: a Paradigm for Public Health Genetics Policy Development: Proceedings of a 1997 Workshop
• Journal Article:
  Morbidity and Mortality Weekly Report (MMWR): Recommendations and Reports
• Personal Author:
  Cono, Joanne, 1962- ; Farrell, Philip M. ; Hannon, W. Harry ; Khoury, Muin J. ; Qualls, Noreen L.
• Corporate Authors:
  National Center for Environmental Health (U.S.) ; National Center for Environmental Health (U.S.), Division of Environmental Hazards and Health Effects. ; National Center for Environmental Health (U.S.), Division of Environmental Health Laboratory Sciences. ; National Center for Environmental Health (U.S.), Office of Genetics and Disease Prevention.
• Description:
  Cystic fibrosis (CF) is a genetic disease that can be detected in newborn infants (i.e., those aged < or = 1 month) by immunotrypsinogen testing. The sensitivity and specificity of such testing can now be improved as a result of the recent discovery of the Cystic Fibrosis Transmembrane Conductance Regulatory (CFTR) gene. Although limited CF screening for newborns has been used since the 1980s, the clinical, social, and economic outcomes of population-based screening are controversial. During January 1997, a workshop was convened at CDC in Atlanta, Georgia to discuss the benefits and risks associated with screening newborns for CF and to develop public health policy concerning such screening. The workshop planning committee comprised representatives from CDC, the Cystic Fibrosis Foundation, the National Institutes of Health, and the University of Wisconsin. Experts in the fields of CF, public health, the screening of newborns, and economics also contributed to discussions. Workshop participants addressed a) benefits and risks, b) laboratory testing, and c) economics concerning the implementation of routine CF screening for newborns. Summaries of these discussions and the resulting workshop recommendations are presented in this report. These recommendations, developed by workshop participants, will be useful to medical and public health professionals and state policymakers who are evaluating the merits of population-based screening of newborns for CF.
  
  Includes bibliographical references (22-24).
  
  
• Subjects:
  Clinical Laboratory Techniques Cystic Fibrosis Cystic Fibrosis Transmembrane Conductance Regulator Diagnosis Economics Genetics Genetic Testing Heterozygote Detection Immunology Infant, Newborn Mass Screening Methods Prevention & Control Standards Trypsinogen

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• Source:
  Morbidity and Mortality Weekly Report (MMWR): Recommendations and Reports, 1997; v. 46, no. 16
• Series:
  Recommendations and Reports: Morbidity and Mortality Weekly Report (MMWR)
• ISSN:
  1057-5987 (print) ; 1545-8601 (digital)
• Pubmed ID:
  9408048
• Document Type:
  Journal Issue
• Genre:
  Conference Publications
• Pages in Document:
  31 pdf pages
• Volume:
  46
• Issue:
  16
• Collection(s):
  Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:5deaabc70db1cfcf8fae099d02362e96dcfd6fc23f18c6b628b2bc2cc28afbb05f160a7b6e1956d099e8a2e206be367bed45bf6316603d8758ea2383a5883fa2
• Download URL:
  https://stacks.cdc.gov/view/cdc/13355/cdc_13355_DS1.pdf
• File Type:
  [PDF - 296.52 KB ]