Vaccine patterns among patients diagnosed with Guillain-Barré Syndrome and matched counterparts in a Medicare supplemental population, 2000–2020

Details

• Alternative Title:
  Vaccine
• Personal Author:
  Eiffert, Samantha R ; Stürmer, Til ; Thorpe, Carolyn T ; Traub, Rebecca ; Raman, Sudha R. ; Pate, Virginia ; Kinlaw, Alan C
• Description:
  Some vaccines have a small risk of Guillain-Barré Syndrome (GBS), a rare autoimmune disorder characterized by paralysis if untreated. The CDC's Advisory Committee on Immunization Practices (ACIP) guidelines do not consider GBS a precaution for future vaccines unless GBS developed within six weeks after a tetanus-toxoid-containing vaccine or influenza vaccine. Our goal was to describe vaccine patterns before and after GBS diagnosis. We matched each of 709 patients diagnosed with GBS from 2002 to 2020 with Medicare supplemental insurance to 10 counterparts without GBS (1:10) on age and sex. Propensity score-based weighting balanced covariates between groups, and we estimated weighted mean cumulative counts (wMCC) of vaccines/person before and after GBS diagnosis. Among patients with GBS, 7% were diagnosed within 42 days after a vaccine. Prior to GBS diagnosis, the wMCC of vaccines per person was similar between GBS cases and matched counterparts, but after two years of follow-up, GBS patients received 21 fewer vaccines/100 people than counterparts (wMCC difference -0.21 vaccines/person, 95% CI -0.24 to -0.18); GBS patients received 16 vaccines/100 people while matched counterparts received 36/100. Vaccine use was reduced following GBS diagnosis despite no ACIP precaution for most (93%) patients in this study. The observed drop in vaccines after GBS diagnosis indicates a disconnect between clinical practice and current recommendations.
• Subjects:
  Aged Guillain-Barre Syndrome Humans Influenza Vaccines Medicare Tetanus Toxoid United States Vaccination
• Source:
  Vaccine. 41(39):5763-5768
• Pubmed ID:
  37573203
• Pubmed Central ID:
  PMC10528847
• Document Type:
  Journal Article
• Funding:
  R01 HL118255/HL/NHLBI NIH HHSUnited States/ ; UM1 TR004406/TR/NCATS NIH HHSUnited States/ ; UL1 TR002489/TR/NCATS NIH HHSUnited States/ ; R01 MD011680/MD/NIMHD NIH HHSUnited States/ ; U01 DD001293/DD/NCBDD CDC HHSUnited States/ ; R01 CA174453/CA/NCI NIH HHSUnited States/ ; R01 AG056479/AG/NIA NIH HHSUnited States/ ; R01 AG079219/AG/NIA NIH HHSUnited States/
• Volume:
  41
• Issue:
  39
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:06cabb172263003726657b5f0dab11de11cd24dd1b45f569e245ebea18c3536c11a8678c6ee8131b5ba1999ded6962bc74edb936481eabd85ed34d3c7ef1bd9d
• Download URL:
  https://stacks.cdc.gov/view/cdc/133518/cdc_133518_DS1.pdf
• File Type:
  [PDF - 860.63 KB ]