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Ionising radiation and solid cancer mortality among United States nuclear facility workers
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8 02 2023
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Source: Int J Epidemiol. 52(4):1015-1024
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Alternative Title:Int J Epidemiol
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Description:Background:
The risk of solid cancers from low-level, protracted ionising radiation is not well characterized. Nuclear workers provide valuable information on the effects of ionising radiation in contemporary exposure scenarios relevant to workers and the public.
Methods:
We evaluated the association between penetrating ionising radiation exposure and solid cancer mortality among a pooled cohort of nuclear workers in the United States, with extended follow-up to examine cancers with long latencies.
Results:
For the association between ionising radiation exposure and all solid cancer mortality we observed an elevated rate (ERR Sv−1=0.19; 95%CI: −0.10, 0.52), which was higher among a contemporary subcohort of workers first hired 1960 or later (ERR Sv−1= 2.23; 95% CI: 1.13, 3.49). Similarly, we observed an elevated rate for lung cancer mortality (ERR Sv−1= 0.65; 0.09, 1.30) which was higher among contemporary hires (ERR Sv−1= 2.90; 95% CI: 1.00, 5.26).
Conclusions:
Although concerns remain about confounding, measurement error, and precision, this analysis strengthens the evidence base indicating there are radiogenic risks for several solid cancer types.
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Pubmed ID:37253388
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Pubmed Central ID:PMC10527884
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