Clinical Characteristics of Corynebacterium ulcerans Infection, Japan

Yamamoto, Akihiko; Hifumi, Toru; Ato, Manabu; Iwaki, Masaaki; Senoh, Mitsutoshi; Hatanaka, Akio; Nureki, Shinichi; Noguchi, Yoshihiro; Hirose, Tomoko; Yoshimura, Yukihiro; Urakawa, Takaaki; Hori, Shiro; Nakada, Hiroto; Terada, Tomomasa; Ishifuji, Tomoko; Matsuyama, Hisayo; Kinebuchi, Takahiro; Fukushima, Atsuhito; Wake, Koji; Otsuji, Ken; Endo, Takeru; Toyoshima, Hirokazu; Yasuda, Ikkoh; Tanaka, Takeshi; Takahashi, Naoki; Okada, Kensaku; Hayashi, Toshimasa; Kusano, Taizo; Koriyama, Minami; Otani, Norio; Takahashi, Motohide

doi:10.3201/eid2908.220058

i

Clinical Characteristics of Corynebacterium ulcerans Infection, Japan

Supporting Files Public Domain

8 2023
By Yamamoto, Akihiko ; Hifumi, Toru ; Ato, Manabu ; ...

File Language:

English

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Alternative Title:

Emerg Infect Dis
Personal Author:

Yamamoto, Akihiko ; Hifumi, Toru ; Ato, Manabu ; Iwaki, Masaaki ; Senoh, Mitsutoshi ; Hatanaka, Akio ; Nureki, Shinichi ; Noguchi, Yoshihiro ; Hirose, Tomoko ; Yoshimura, Yukihiro ; Urakawa, Takaaki ; Hori, Shiro ; Nakada, Hiroto ; Terada, Tomomasa ; Ishifuji, Tomoko ; Matsuyama, Hisayo ; Kinebuchi, Takahiro ; Fukushima, Atsuhito ; Wake, Koji ; Otsuji, Ken ; Endo, Takeru ; Toyoshima, Hirokazu ; Yasuda, Ikkoh ; Tanaka, Takeshi ; Takahashi, Naoki ; Okada, Kensaku ; Hayashi, Toshimasa ; Kusano, Taizo ; Koriyama, Minami ; Otani, Norio ; Takahashi, Motohide
Description:

Corynebacterium ulcerans is a closely related bacterium to the diphtheria bacterium C. diphtheriae, and some C. ulcerans strains produce toxins that are similar to diphtheria toxin. C. ulcerans is widely distributed in the environment and is considered one of the most harmful pathogens to livestock and wildlife. Infection with C. ulcerans can cause respiratory or nonrespiratory symptoms in patients. Recently, the microorganism has been increasingly recognized as an emerging zoonotic agent of diphtheria-like illness in Japan. To clarify the overall clinical characteristics, treatment-related factors, and outcomes of C. ulcerans infection, we analyzed 34 cases of C. ulcerans that occurred in Japan during 2001-2020. During 2010-2020, the incidence rate of C. ulcerans infection increased markedly, and the overall mortality rate was 5.9%. It is recommended that adults be vaccinated with diphtheria toxoid vaccine to prevent the spread of this infection.
Subjects:

Adult Bacteria Bacterial Infections Clinical Characteristics Of Corynebacterium Ulcerans Infection, Japan Companion Animals Corynebacterium Corynebacterium Diphtheriae Corynebacterium Infections Corynebacterium Ulcerans Diphtheria Diphtheria Toxin Diphtheria Toxoid Humans Japan Respiratory Infections Synopsis
Source:

Emerg Infect Dis. 2023; 29(8):1505-1515
Pubmed ID:

37486266
Pubmed Central ID:

PMC10370844
Document Type:

Journal Article
Volume:

29
Issue:

8
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:2384c31e6207c4d3f1ba6c4a34462afdf2d5d2bbea06f1e0b9fcc1bb04632196
Download URL:

https://stacks.cdc.gov/view/cdc/132596/cdc_132596_DS1.pdf
File Type:

[PDF - 2.06 MB ]

File Language:

English

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